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. 1996 Nov;64(11):4580–4585. doi: 10.1128/iai.64.11.4580-4585.1996

Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis.

G W Anderson Jr 1, S E Leary 1, E D Williamson 1, R W Titball 1, S L Welkos 1, P L Worsham 1, A M Friedlander 1
PMCID: PMC174416  PMID: 8890210

Abstract

The purified recombinant V antigen from Yersinia pestis, expressed in Escherichia coli and adsorbed to aluminum hydroxide, an adjuvant approved for human use, was used to immunize outbred Hsd:ND4 mice subcutaneously. Immunization protected mice from lethal bubonic and pneumonic plague caused by CO92, a wild-type F1+ strain, or by the isogenic F1- strain C12. This work demonstrates that a subunit plague vaccine formulated for human use provides significant protection against bubonic plague caused by an F1- strain (C12) or against substantial aerosol challenges from either F1+ (CO92) or F1-(C12) Y. pestis.

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Selected References

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