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. 2001 Apr;77(2):93–96. doi: 10.1136/sti.77.2.93

Gene therapy for HIV

A Lever 1
PMCID: PMC1744275  PMID: 11287684

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adelson M. E., Martinand-Mari C., Iacono K. T., Muto N. F., Suhadolnik R. J. Inhibition of human immunodeficiency virus (HIV-1) replication in SupT1 cells transduced with an HIV-1 LTR-driven PKR cDNA construct. Eur J Biochem. 1999 Sep;264(3):806–815. doi: 10.1046/j.1432-1327.1999.00661.x. [DOI] [PubMed] [Google Scholar]
  2. Aguilar-Cordova E., Chinen J., Donehower L. A., Harper J. W., Rice A. P., Butel J. S., Belmont J. W. Inhibition of HIV-1 by a double transdominant fusion gene. Gene Ther. 1995 May;2(3):181–186. [PubMed] [Google Scholar]
  3. Andäng M., Hinkula J., Hotchkiss G., Larsson S., Britton S., Wong-Staal F., Wahren B., Ahrlund-Richter L. Dose-response resistance to HIV-1/MuLV pseudotype virus ex vivo in a hairpin ribozyme transgenic mouse model. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12749–12753. doi: 10.1073/pnas.96.22.12749. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Baltimore D. Gene therapy. Intracellular immunization. Nature. 1988 Sep 29;335(6189):395–396. doi: 10.1038/335395a0. [DOI] [PubMed] [Google Scholar]
  5. Bednarik D. P., Mosca J. D., Raj N. B., Pitha P. M. Inhibition of human immunodeficiency virus (HIV) replication by HIV-trans-activated alpha 2-interferon. Proc Natl Acad Sci U S A. 1989 Jul;86(13):4958–4962. doi: 10.1073/pnas.86.13.4958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Berkhout B., van Wamel J. L. Inhibition of human immunodeficiency virus expression by sense transcripts encoding the retroviral leader RNA. Antiviral Res. 1995 Mar;26(2):101–115. doi: 10.1016/0166-3542(94)00068-j. [DOI] [PubMed] [Google Scholar]
  7. Bevec D., Volc-Platzer B., Zimmermann K., Dobrovnik M., Hauber J., Veres G., Böhnlein E. Constitutive expression of chimeric neo-Rev response element transcripts suppresses HIV-1 replication in human CD4+ T lymphocytes. Hum Gene Ther. 1994 Feb;5(2):193–201. doi: 10.1089/hum.1994.5.2-193. [DOI] [PubMed] [Google Scholar]
  8. Buchschacher G. L., Jr, Freed E. O., Panganiban A. T. Cells induced to express a human immunodeficiency virus type 1 envelope gene mutant inhibit the spread of wild-type virus. Hum Gene Ther. 1992 Aug;3(4):391–397. doi: 10.1089/hum.1992.3.4-391. [DOI] [PubMed] [Google Scholar]
  9. Caputo A., Rossi C., Bozzini R., Betti M., Grossi M. P., Barbanti-Brodano G., Balboni P. G. Studies on the effect of the combined expression of anti-tat and anti-rev genes on HIV-1 replication. Gene Ther. 1997 Apr;4(4):288–295. doi: 10.1038/sj.gt.3300393. [DOI] [PubMed] [Google Scholar]
  10. Caruso M., Klatzmann D. Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):182–186. doi: 10.1073/pnas.89.1.182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Chang H. K., Gendelman R., Lisziewicz J., Gallo R. C., Ensoli B. Block of HIV-1 infection by a combination of antisense tat RNA and TAR decoys: a strategy for control of HIV-1. Gene Ther. 1994 May;1(3):208–216. [PubMed] [Google Scholar]
  12. Chatterjee S., Johnson P. R., Wong K. K., Jr Dual-target inhibition of HIV-1 in vitro by means of an adeno-associated virus antisense vector. Science. 1992 Nov 27;258(5087):1485–1488. doi: 10.1126/science.1359646. [DOI] [PubMed] [Google Scholar]
  13. Chen C. J., Banerjea A. C., Harmison G. G., Haglund K., Schubert M. Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates. Nucleic Acids Res. 1992 Sep 11;20(17):4581–4589. doi: 10.1093/nar/20.17.4581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Chen J. D., Bai X., Yang A. G., Cong Y., Chen S. Y. Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy. Nat Med. 1997 Oct;3(10):1110–1116. doi: 10.1038/nm1097-1110. [DOI] [PubMed] [Google Scholar]
  15. Chen S. S., Lee S. F., Chuang C. K., Raj V. S. trans-dominant interference with human immunodeficiency virus type 1 replication and transmission in CD4(+) cells by an envelope double mutant. J Virol. 1999 Oct;73(10):8290–8302. doi: 10.1128/jvi.73.10.8290-8302.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Chuah M. K., VandenDriessche T., Chang H. K., Ensoli B., Morgan R. A. Inhibition of human immunodeficiency virus type-1 by retroviral vectors expressing antisense-TAR. Hum Gene Ther. 1994 Dec;5(12):1467–1475. doi: 10.1089/hum.1994.5.12-1467. [DOI] [PubMed] [Google Scholar]
  17. Dropulić B., Hermánková M., Pitha P. M. A conditionally replicating HIV-1 vector interferes with wild-type HIV-1 replication and spread. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11103–11108. doi: 10.1073/pnas.93.20.11103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Harrison G. S., Long C. J., Curiel T. J., Maxwell F., Maxwell I. H. Inhibition of human immunodeficiency virus-1 production resulting from transduction with a retrovirus containing an HIV-regulated diphtheria toxin A chain gene. Hum Gene Ther. 1992 Oct;3(5):461–469. doi: 10.1089/hum.1992.3.5-461. [DOI] [PubMed] [Google Scholar]
  19. Joshi S., Van Brunschot A., Asad S., van der Elst I., Read S. E., Bernstein A. Inhibition of human immunodeficiency virus type 1 multiplication by antisense and sense RNA expression. J Virol. 1991 Oct;65(10):5524–5530. doi: 10.1128/jvi.65.10.5524-5530.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Leavitt M. C., Yu M., Wong-Staal F., Looney D. J. Ex vivo transduction and expansion of CD4+ lymphocytes from HIV + donors: prelude to a ribozyme gene therapy trial. Gene Ther. 1996 Jul;3(7):599–606. [PubMed] [Google Scholar]
  21. Lee S. W., Gallardo H. F., Gaspar O., Smith C., Gilboa E. Inhibition of HIV-1 in CEM cells by a potent TAR decoy. Gene Ther. 1995 Aug;2(6):377–384. [PubMed] [Google Scholar]
  22. Levin A. A. A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim Biophys Acta. 1999 Dec 10;1489(1):69–84. doi: 10.1016/s0167-4781(99)00140-2. [DOI] [PubMed] [Google Scholar]
  23. Lisziewicz J., Sun D., Smythe J., Lusso P., Lori F., Louie A., Markham P., Rossi J., Reitz M., Gallo R. C. Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy in AIDS. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8000–8004. doi: 10.1073/pnas.90.17.8000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Lisziewicz J., Sun D., Weichold F. F., Thierry A. R., Lusso P., Tang J., Gallo R. C., Agrawal S. Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7942–7946. doi: 10.1073/pnas.91.17.7942. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Mhashilkar A. M., LaVecchio J., Eberhardt B., Porter-Brooks J., Boisot S., Dove J. H., Pumphrey C., Li X., Weissmahr R. N., Ring D. B. Inhibition of human immunodeficiency virus type 1 replication in vitro in acutely and persistently infected human CD4+ mononuclear cells expressing murine and humanized anti-human immunodeficiency virus type 1 Tat single-chain variable fragment intrabodies. Hum Gene Ther. 1999 Jun 10;10(9):1453–1467. doi: 10.1089/10430349950017798. [DOI] [PubMed] [Google Scholar]
  26. Michienzi A., Conti L., Varano B., Prislei S., Gessani S., Bozzoni I. Inhibition of human immunodeficiency virus type 1 replication by nuclear chimeric anti-HIV ribozymes in a human T lymphoblastoid cell line. Hum Gene Ther. 1998 Mar 20;9(5):621–628. doi: 10.1089/hum.1998.9.5-621. [DOI] [PubMed] [Google Scholar]
  27. Miele G., Lever A. M. Expression of mutant and wild-type gag proteins for gene therapy in HIV-1 infection. Gene Ther. 1996 Apr;3(4):357–361. [PubMed] [Google Scholar]
  28. Muto N. F., Martinand-Mari C., Adelson M. E., Suhadolnik R. J. Inhibition of replication of reactivated human immunodeficiency virus type 1 (HIV-1) in latently infected U1 cells transduced with an HIV-1 long terminal repeat-driven PKR cDNA construct. J Virol. 1999 Nov;73(11):9021–9028. doi: 10.1128/jvi.73.11.9021-9028.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Olivetta E., Pugliese K., Bona R., D'Aloja P., Ferrantelli F., Santarcangelo A. C., Mattia G., Verani P., Federico M. cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails. J Virol. 2000 Jan;74(1):483–492. doi: 10.1128/jvi.74.1.483-492.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Orsini M. J., Debouck C. M. Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm. J Virol. 1996 Nov;70(11):8055–8063. doi: 10.1128/jvi.70.11.8055-8063.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Reddy T. R., Xu W., Mau J. K., Goodwin C. D., Suhasini M., Tang H., Frimpong K., Rose D. W., Wong-Staal F. Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev. Nat Med. 1999 Jun;5(6):635–642. doi: 10.1038/9479. [DOI] [PubMed] [Google Scholar]
  32. Rhodes A., James W. Inhibition of human immunodeficiency virus replication in cell culture by endogenously synthesized antisense RNA. J Gen Virol. 1990 Sep;71(Pt 9):1965–1974. doi: 10.1099/0022-1317-71-9-1965. [DOI] [PubMed] [Google Scholar]
  33. Sawaya B. E., Khalili K., Rappaport J., Serio D., Chen W., Srinivasan A., Amini S. Suppression of HIV-1 transcription and replication by a Vpr mutant. Gene Ther. 1999 May;6(5):947–950. doi: 10.1038/sj.gt.3300907. [DOI] [PubMed] [Google Scholar]
  34. Sczakiel G., Pawlita M. Inhibition of human immunodeficiency virus type 1 replication in human T cells stably expressing antisense RNA. J Virol. 1991 Jan;65(1):468–472. doi: 10.1128/jvi.65.1.468-472.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Stein C. A. Phosphorothioate antisense oligodeoxynucleotides: questions of specificity. Trends Biotechnol. 1996 May;14(5):147–149. doi: 10.1016/0167-7799(96)20006-X. [DOI] [PubMed] [Google Scholar]
  36. Sullenger B. A., Cech T. R. Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science. 1993 Dec 3;262(5139):1566–1569. doi: 10.1126/science.8248806. [DOI] [PubMed] [Google Scholar]
  37. Sullenger B. A., Gallardo H. F., Ungers G. E., Gilboa E. Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation. J Virol. 1991 Dec;65(12):6811–6816. doi: 10.1128/jvi.65.12.6811-6816.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Sullenger B. A., Gallardo H. F., Ungers G. E., Gilboa E. Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication. Cell. 1990 Nov 2;63(3):601–608. doi: 10.1016/0092-8674(90)90455-n. [DOI] [PubMed] [Google Scholar]
  39. Symensma T. L., Giver L., Zapp M., Takle G. B., Ellington A. D. RNA aptamers selected to bind human immunodeficiency virus type 1 Rev in vitro are Rev responsive in vivo. J Virol. 1996 Jan;70(1):179–187. doi: 10.1128/jvi.70.1.179-187.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. VandenDriessche T., Chuah M. K., Chiang L., Chang H. K., Ensoli B., Morgan R. A. Inhibition of clinical human immunodeficiency virus (HIV) type 1 isolates in primary CD4+ T lymphocytes by retroviral vectors expressing anti-HIV genes. J Virol. 1995 Jul;69(7):4045–4052. doi: 10.1128/jvi.69.7.4045-4052.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Ventura M., Wang P., Franck N., Saragosti S. Ribozyme targeting of HIV-1 LTR. Biochem Biophys Res Commun. 1994 Sep 15;203(2):889–898. doi: 10.1006/bbrc.1994.2266. [DOI] [PubMed] [Google Scholar]
  42. Vieillard V., Jouveshomme S., Leflour N., Jean-Pierre E., Debre P., De Maeyer E., Autran B. Transfer of human CD4(+) T lymphocytes producing beta interferon in Hu-PBL-SCID mice controls human immunodeficiency virus infection. J Virol. 1999 Dec;73(12):10281–10288. doi: 10.1128/jvi.73.12.10281-10288.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Vieillard V., Lauret E., Rousseau V., De Maeyer E. Blocking of retroviral infection at a step prior to reverse transcription in cells transformed to constitutively express interferon beta. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2689–2693. doi: 10.1073/pnas.91.7.2689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Wang L., Witherington C., King A., Gerlach W. L., Carr A., Penny R., Cooper D., Symonds G., Sun L. Q. Preclinical characterization of an anti-tat ribozyme for therapeutic application. Hum Gene Ther. 1998 Jun 10;9(9):1283–1291. doi: 10.1089/hum.1998.9.9-1283. [DOI] [PubMed] [Google Scholar]
  45. Woffendin C., Ranga U., Yang Z., Xu L., Nabel G. J. Expression of a protective gene-prolongs survival of T cells in human immunodeficiency virus-infected patients. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2889–2894. doi: 10.1073/pnas.93.7.2889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Woffendin C., Yang Z. Y., Udaykumar, Xu L., Yang N. S., Sheehy M. J., Nabel G. J. Nonviral and viral delivery of a human immunodeficiency virus protective gene into primary human T cells. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11581–11585. doi: 10.1073/pnas.91.24.11581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Yamada O., Yu M., Yee J. K., Kraus G., Looney D., Wong-Staal F. Intracellular immunization of human T cells with a hairpin ribozyme against human immunodeficiency virus type 1. Gene Ther. 1994 Jan;1(1):38–45. [PubMed] [Google Scholar]
  48. Yu M., Leavitt M. C., Maruyama M., Yamada O., Young D., Ho A. D., Wong-Staal F. Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):699–703. doi: 10.1073/pnas.92.3.699. [DOI] [PMC free article] [PubMed] [Google Scholar]

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