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Infection and Immunity logoLink to Infection and Immunity
. 1996 Nov;64(11):4859–4862. doi: 10.1128/iai.64.11.4859-4862.1996

Differential binding of Nocardia asteroides in the murine lung and brain suggests multiple ligands on the nocardial surface.

B L Beaman 1
PMCID: PMC174459  PMID: 8890253

Abstract

The adherence of Nocardia asteroides in the murine brain and lungs was determined. Virulent strains had increased adherence in the brain and lungs, whereas less virulent strains bound in either the brain or lungs. Nocardiae that attached apically penetrated host cells. Multiple receptors on the nocardial surface may be involved in this differential attachment and penetration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beaman B. L., Beaman L. Nocardia species: host-parasite relationships. Clin Microbiol Rev. 1994 Apr;7(2):213–264. doi: 10.1128/cmr.7.2.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beaman B. L., Goldstein E., Gershwin M. E., Maslan S., Lippert W. Lung response to congenitally athymic (nude), heterozygous, and Swiss Webster mice to aerogenic and intranasal infection by Nocardia asteroides. Infect Immun. 1978 Dec;22(3):867–877. doi: 10.1128/iai.22.3.867-877.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beaman B. L., Maslan S. Effect of cyclophosphamide on experimental Nocardia asteroides infection in mice. Infect Immun. 1977 Jun;16(3):995–1004. doi: 10.1128/iai.16.3.995-1004.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beaman B. L., Maslan S., Scates S., Rosen J. Effect of route on inoculation on host resistance to Nocardia. Infect Immun. 1980 Apr;28(1):185–189. doi: 10.1128/iai.28.1.185-189.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Beaman B. L., Maslan S. Virulence of Nocardia asteroides during its growth cycle. Infect Immun. 1978 Apr;20(1):290–295. doi: 10.1128/iai.20.1.290-295.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Beaman B. L., Ogata S. A. Ultrastructural analysis of attachment to and penetration of capillaries in the murine pons, midbrain, thalamus, and hypothalamus by Nocardia asteroides. Infect Immun. 1993 Mar;61(3):955–965. doi: 10.1128/iai.61.3.955-965.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Beaman L., Beaman B. L. Differences in the interactions of Nocardia asteroides with macrophage, endothelial, and astrocytoma cell lines. Infect Immun. 1994 May;62(5):1787–1798. doi: 10.1128/iai.62.5.1787-1798.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Brechot J. M., Capron F., Prudent J., Rochemaure J. Unexpected pulmonary nocardiosis in a non-immunocompromised patient. Thorax. 1987 Jun;42(6):479–480. doi: 10.1136/thx.42.6.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Camp M., Mehta J. B., Whitson M. Bronchiolitis obliterans and Nocardia asteroides infection of the lung. Chest. 1987 Dec;92(6):1107–1108. doi: 10.1378/chest.92.6.1107. [DOI] [PubMed] [Google Scholar]
  10. Hamal P. B. Primary pulmonary nocardiosis: case report. Thorax. 1974 May;29(3):382–386. doi: 10.1136/thx.29.3.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ogata S. A., Beaman B. L. Adherence of Nocardia asteroides within the murine brain. Infect Immun. 1992 May;60(5):1800–1805. doi: 10.1128/iai.60.5.1800-1805.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schulman L. L., Enson Y. Nocardia pneumonitis and the adult respiratory distress syndrome. Am J Med Sci. 1987 May;293(5):315–319. doi: 10.1097/00000441-198705000-00006. [DOI] [PubMed] [Google Scholar]

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