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. 2004 Aug;80(4):277–279. doi: 10.1136/sti.2004.009753

Changing epidemiology of genital herpes simplex virus infection in Melbourne, Australia, between 1980 and 2003

T Tran 1, J Druce 1, M Catton 1, H Kelly 1, C Birch 1
PMCID: PMC1744857  PMID: 15295125

Abstract

Objective: To investigate changes in the proportions of patients infected with genital herpes simplex virus (HSV) types 1 and 2 from 1980 to 2003 in Melbourne, Australia.

Methods: A total of 25 372 patients were studied retrospectively. The proportions of HSV-1 and HSV-2 detected in these individuals were analysed by age, sex, and genital site.

Results: In 1980 only 15.8% of HSV positive genital specimens were HSV-1 compared to 34.9% in 2003. In 2003 HSV-1 was detected in 77% of patients aged less than 20 years. Females were more likely to be infected with HSV-1, although the rate of increased detection was more pronounced in males. Except for females over the age of 40, the trend for the increase in HSV-1 was detected in all age groups. No specific genital site in either sex was associated with the increase.

Conclusions: The proportion of genital HSV-1 has increased in Australian patients, although HSV-2 is still the most common cause of genital infection. Confirmation of HSV type is necessary for optimal patient management.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Birch C. J., Tyssen D. P., Tachedjian G., Doherty R., Hayes K., Mijch A., Lucas C. R. Clinical effects and in vitro studies of trifluorothymidine combined with interferon-alpha for treatment of drug-resistant and -sensitive herpes simplex virus infections. J Infect Dis. 1992 Jul;166(1):108–112. doi: 10.1093/infdis/166.1.108. [DOI] [PubMed] [Google Scholar]
  2. Cowan F. M. Commentary: developing preventive strategies in Europe. Int J Epidemiol. 2001 Jun;30(3):588–589. doi: 10.1093/ije/30.3.588. [DOI] [PubMed] [Google Scholar]
  3. Druce Julian, Catton Mike, Chibo Doris, Minerds Kirsty, Tyssen David, Kostecki Renata, Maskill Bill, Leong-Shaw Wendy, Gerrard Marie, Birch Chris. Utility of a multiplex PCR assay for detecting herpesvirus DNA in clinical samples. J Clin Microbiol. 2002 May;40(5):1728–1732. doi: 10.1128/JCM.40.5.1728-1732.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Engelberg Rebecca, Carrell David, Krantz Elizabeth, Corey Lawrence, Wald Anna. Natural history of genital herpes simplex virus type 1 infection. Sex Transm Dis. 2003 Feb;30(2):174–177. doi: 10.1097/00007435-200302000-00015. [DOI] [PubMed] [Google Scholar]
  5. Lafferty W. E., Downey L., Celum C., Wald A. Herpes simplex virus type 1 as a cause of genital herpes: impact on surveillance and prevention. J Infect Dis. 2000 Apr 13;181(4):1454–1457. doi: 10.1086/315395. [DOI] [PubMed] [Google Scholar]
  6. Langenberg A. G., Corey L., Ashley R. L., Leong W. P., Straus S. E. A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group. N Engl J Med. 1999 Nov 4;341(19):1432–1438. doi: 10.1056/NEJM199911043411904. [DOI] [PubMed] [Google Scholar]
  7. Lippelt Lars, Braun Rüdiger W., Kühn Joachim E. Genital herpes simplex virus type 1 infection: new fields for an old acquaintance? Intervirology. 2002;45(1):2–5. doi: 10.1159/000050080. [DOI] [PubMed] [Google Scholar]
  8. Löwhagen Gun-Britt, Tunbäck Petra, Bergström Tomas. Proportion of herpes simplex virus (HSV) type 1 and type 2 among genital and extragenital HSV isolates. Acta Derm Venereol. 2002;82(2):118–120. doi: 10.1080/00015550252948158. [DOI] [PubMed] [Google Scholar]
  9. Mertz G. J. Genital herpes simplex virus infections. Med Clin North Am. 1990 Nov;74(6):1433–1454. doi: 10.1016/s0025-7125(16)30489-8. [DOI] [PubMed] [Google Scholar]
  10. Nilsen A., Myrmel H. Changing trends in genital herpes simplex virus infection in Bergen, Norway. Acta Obstet Gynecol Scand. 2000 Aug;79(8):693–696. [PubMed] [Google Scholar]
  11. Ribes J. A., Steele A. D., Seabolt J. P., Baker D. J. Six-year study of the incidence of herpes in genital and nongenital cultures in a central Kentucky medical center patient population. J Clin Microbiol. 2001 Sep;39(9):3321–3325. doi: 10.1128/JCM.39.9.3321-3325.2001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Roberts Craig M., Pfister John R., Spear Scott J. Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. Sex Transm Dis. 2003 Oct;30(10):797–800. doi: 10.1097/01.OLQ.0000092387.58746.C7. [DOI] [PubMed] [Google Scholar]
  13. Ross J. D., Smith I. W., Elton R. A. The epidemiology of herpes simplex types 1 and 2 infection of the genital tract in Edinburgh 1978-1991. Genitourin Med. 1993 Oct;69(5):381–383. doi: 10.1136/sti.69.5.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Samra Zmira, Scherf Edna, Dan Michael. Herpes simplex virus type 1 is the prevailing cause of genital herpes in the Tel Aviv area, Israel. Sex Transm Dis. 2003 Oct;30(10):794–796. doi: 10.1097/01.OLQ.0000079517.04451.79. [DOI] [PubMed] [Google Scholar]
  15. Scoular A., Leask B. G., Carrington D. Changing trends in genital herpes due to Herpes simplex virus type 1 in Glasgow, 1985-88. Genitourin Med. 1990 Jun;66(3):226–226. doi: 10.1136/sti.66.3.226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Strutt M., Bailey J., Tenant-Flowers M., Graham D., Zuckerman M. Ethnic variation in type of genital herpes simplex virus infection in a South London genitourinary medicine clinic. J Med Virol. 2003 Jan;69(1):108–110. doi: 10.1002/jmv.10251. [DOI] [PubMed] [Google Scholar]
  17. Tayal S. C., Pattman R. S. High prevalence of herpes simplex virus type 1 in female anogenital herpes simplex in Newcastle upon Tyne 1983-92. Int J STD AIDS. 1994 Sep-Oct;5(5):359–361. doi: 10.1177/095646249400500514. [DOI] [PubMed] [Google Scholar]
  18. Wald A. New therapies and prevention strategies for genital herpes. Clin Infect Dis. 1999 Jan;28 (Suppl 1):S4–13. doi: 10.1086/514723. [DOI] [PubMed] [Google Scholar]
  19. Xu Fujie, Schillinger Julia A., Sternberg Maya R., Johnson Robert E., Lee Francis K., Nahmias Andre J., Markowitz Lauri E. Seroprevalence and coinfection with herpes simplex virus type 1 and type 2 in the United States, 1988-1994. J Infect Dis. 2002 Mar 22;185(8):1019–1024. doi: 10.1086/340041. [DOI] [PubMed] [Google Scholar]

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