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. 1998 Jul;53(7):549–553. doi: 10.1136/thx.53.7.549

Birth weight, childhood lower respiratory tract infection, and adult lung function

S Shaheen 1, J Sterne 1, J Tucker 1, C Florey 1
PMCID: PMC1745265  PMID: 9797752

Abstract

BACKGROUND—Historical cohort studies in England have found that impaired fetal growth and lower respiratory tract infections in early childhood are associated with lower levels of lung function in late adult life. These relations are investigated in a similar study in Scotland.
METHODS—In 1985-86 a follow up study was carried out of 1070 children who had been born in St Andrew's from 1921 to 1935 and followed from birth to 14 years of age by the Mackenzie Institute for Medical Research. Recorded information included birth weight and respiratory illnesses. The lung function of 239 of these individuals was measured.
RESULTS—There was no association between birth weight and lung function. Pneumonia before two years of age was associated with a difference in mean forced expiratory volume in one second (FEV1) of −0.39 litres (95% confidence interval (CI) −0.67, −0.11; p = 0.007) and in mean forced vital capacity (FVC) of −0.60 litres (95% CI −0.92, −0.28; p<0.001), after controlling for age, sex, height, smoking, type of spirometer, and other illnesses before two years. Similar reductions were seen in men and women. Bronchitis before two years was associated with smaller deficits in FEV1 and FVC. Asthma or wheeze at two years and older and cough after five years were also associated with a reduction in FEV1.
CONCLUSIONS—The relation between impaired fetal growth and lower lung function in late adult life seen in previous studies was not confirmed in this cohort. The deficits in FEV1 and FVC associated with pneumonia and bronchitis in the first two years of life are consistent with a causal relation.



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Selected References

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  1. Barker D. J., Godfrey K. M., Fall C., Osmond C., Winter P. D., Shaheen S. O. Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. BMJ. 1991 Sep 21;303(6804):671–675. doi: 10.1136/bmj.303.6804.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barker D. J., Osmond C. Childhood respiratory infection and adult chronic bronchitis in England and Wales. Br Med J (Clin Res Ed) 1986 Nov 15;293(6557):1271–1275. doi: 10.1136/bmj.293.6557.1271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Becroft D. M. Bronchiolitis obliterans, bronchiectasis, and other sequelae of adenovirus type 21 infection in young children. J Clin Pathol. 1971 Feb;24(1):72–82. doi: 10.1136/jcp.24.1.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Britten N., Wadsworth J. Long term respiratory sequelae of whooping cough in a nationally representative sample. Br Med J (Clin Res Ed) 1986 Feb 15;292(6518):441–444. doi: 10.1136/bmj.292.6518.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Castleman W. L., Sorkness R. L., Lemanske R. F., Grasee G., Suyemoto M. M. Neonatal viral bronchiolitis and pneumonia induces bronchiolar hypoplasia and alveolar dysplasia in rats. Lab Invest. 1988 Sep;59(3):387–396. [PubMed] [Google Scholar]
  6. Day M. P., Tucker J. S., Florey C. D., Ogston S., Mason C. M., Donnelly J. D. The Mackenzie Institute Record Study--methods and preliminary findings. Health Bull (Edinb) 1989 Mar;47(2):95–103. [PubMed] [Google Scholar]
  7. Fletcher C., Peto R. The natural history of chronic airflow obstruction. Br Med J. 1977 Jun 25;1(6077):1645–1648. doi: 10.1136/bmj.1.6077.1645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gold D. R., Tager I. B., Weiss S. T., Tosteson T. D., Speizer F. E. Acute lower respiratory illness in childhood as a predictor of lung function and chronic respiratory symptoms. Am Rev Respir Dis. 1989 Oct;140(4):877–884. doi: 10.1164/ajrccm/140.4.877. [DOI] [PubMed] [Google Scholar]
  9. Gold R., Wilt J. C., Adhikari P. K., Macpherson R. I. Adenoviral pneumonia and its complications in infancy and childhood. J Can Assoc Radiol. 1969 Dec;20(4):218–224. [PubMed] [Google Scholar]
  10. Graham N. M. The epidemiology of acute respiratory infections in children and adults: a global perspective. Epidemiol Rev. 1990;12:149–178. doi: 10.1093/oxfordjournals.epirev.a036050. [DOI] [PubMed] [Google Scholar]
  11. HARNETT R. W., MAIR A. Chronic bronchitis and the catarrhal child. Scott Med J. 1963 May;8:175–184. doi: 10.1177/003693306300800502. [DOI] [PubMed] [Google Scholar]
  12. Hanrahan J. P., Tager I. B., Segal M. R., Tosteson T. D., Castile R. G., Van Vunakis H., Weiss S. T., Speizer F. E. The effect of maternal smoking during pregnancy on early infant lung function. Am Rev Respir Dis. 1992 May;145(5):1129–1135. doi: 10.1164/ajrccm/145.5.1129. [DOI] [PubMed] [Google Scholar]
  13. Hughes D. M., Newton-John H., Chay O. M., Landau L. I. Lung function after pertussis. Aust Paediatr J. 1987 Oct;23(5):277–282. doi: 10.1111/j.1440-1754.1987.tb00271.x. [DOI] [PubMed] [Google Scholar]
  14. Johnston I. D., Bland J. M., Ingram D., Anderson H. R., Warner J. O., Lambert H. P. Effect of whooping cough in infancy on subsequent lung function and bronchial reactivity. Am Rev Respir Dis. 1986 Aug;134(2):270–275. doi: 10.1164/arrd.1986.134.2.270. [DOI] [PubMed] [Google Scholar]
  15. Johnston I. D., Strachan D. P., Anderson H. R. Effect of pneumonia and whooping cough in childhood on adult lung function. N Engl J Med. 1998 Feb 26;338(9):581–587. doi: 10.1056/NEJM199802263380904. [DOI] [PubMed] [Google Scholar]
  16. Lang W. R., Howden C. W., Laws J., Burton J. F. Bronchopneumonia with serious sequelae in children with evidence of adenovirus type 21 infection. Br Med J. 1969 Jan 11;1(5636):73–79. doi: 10.1136/bmj.1.5636.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mann S. L., Wadsworth M. E., Colley J. R. Accumulation of factors influencing respiratory illness in members of a national birth cohort and their offspring. J Epidemiol Community Health. 1992 Jun;46(3):286–292. doi: 10.1136/jech.46.3.286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mok J. Y., Simpson H. Outcome for acute bronchitis, bronchiolitis, and pneumonia in infancy. Arch Dis Child. 1984 Apr;59(4):306–309. doi: 10.1136/adc.59.4.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Peto R., Speizer F. E., Cochrane A. L., Moore F., Fletcher C. M., Tinker C. M., Higgins I. T., Gray R. G., Richards S. M., Gilliland J. The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Results from 20 years of prospective observation. Am Rev Respir Dis. 1983 Sep;128(3):491–500. doi: 10.1164/arrd.1983.128.3.491. [DOI] [PubMed] [Google Scholar]
  20. Pullan C. R., Hey E. N. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br Med J (Clin Res Ed) 1982 Jun 5;284(6330):1665–1669. doi: 10.1136/bmj.284.6330.1665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rona R. J., Gulliford M. C., Chinn S. Effects of prematurity and intrauterine growth on respiratory health and lung function in childhood. BMJ. 1993 Mar 27;306(6881):817–820. doi: 10.1136/bmj.306.6881.817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Samet J. M., Tager I. B., Speizer F. E. The relationship between respiratory illness in childhood and chronic air-flow obstruction in adulthood. Am Rev Respir Dis. 1983 Apr;127(4):508–523. doi: 10.1164/arrd.1983.127.4.508. [DOI] [PubMed] [Google Scholar]
  23. Shaheen S. O., Barker D. J., Shiell A. W., Crocker F. J., Wield G. A., Holgate S. T. The relationship between pneumonia in early childhood and impaired lung function in late adult life. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):616–619. doi: 10.1164/ajrccm.149.3.8118627. [DOI] [PubMed] [Google Scholar]
  24. Similä S., Linna O., Lanning P., Heikkinen E., Ala-Houhala M. Chronic lung damage caused by adenovirus type 7: a ten-year follow-up study. Chest. 1981 Aug;80(2):127–131. doi: 10.1378/chest.80.2.127. [DOI] [PubMed] [Google Scholar]
  25. Sly P. D., Soto-Quiros M. E., Landau L. I., Hudson I., Newton-John H. Factors predisposing to abnormal pulmonary function after adenovirus type 7 pneumonia. Arch Dis Child. 1984 Oct;59(10):935–939. doi: 10.1136/adc.59.10.935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Speizer F. E., Tager I. B. Epidemiology of chronic mucus hypersecretion and obstructive airways disease. Epidemiol Rev. 1979;1:124–142. doi: 10.1093/oxfordjournals.epirev.a036206. [DOI] [PubMed] [Google Scholar]
  27. Stein C. E., Kumaran K., Fall C. H., Shaheen S. O., Osmond C., Barker D. J. Relation of fetal growth to adult lung function in south India. Thorax. 1997 Oct;52(10):895–899. doi: 10.1136/thx.52.10.895. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Taylor B., Wadsworth J. Maternal smoking during pregnancy and lower respiratory tract illness in early life. Arch Dis Child. 1987 Aug;62(8):786–791. doi: 10.1136/adc.62.8.786. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Teculescu D. B., Aubry C., Pham Q. T., Locuty J., Deschamps J. P., Manciaux M. Lung function in adolescents after uncomplicated whooping cough in childhood. Eur Respir J. 1989 Sep;2(8):733–735. [PubMed] [Google Scholar]

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