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. 1996 Dec;64(12):5421–5424. doi: 10.1128/iai.64.12.5421-5424.1996

Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins.

S Ruhl 1, A L Sandberg 1, M F Cole 1, J O Cisar 1
PMCID: PMC174542  PMID: 8945600

Abstract

Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge region of the IgA1 heavy chain are receptors for lectin-mediated adhesion of these bacteria.

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Selected References

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