Abstract
BACKGROUND—Asthma is one of the most common chronic diseases in modern society and there is increasing evidence to suggest that its incidence and severity are increasing. There is a high prevalence of usage of complementary medicine for asthma. Herbal preparations have been cited as the third most popular complementary treatment modality by British asthma sufferers. This study was undertaken to determine if there is any evidence for the clinical efficacy of herbal preparations for the treatment of asthma symptoms. METHODS—Four independent literature searches were performed on Medline, Pubmed, Cochrane Library, and Embase. Only randomised clinical trials were included. There were no restrictions on the language of publication. The data were extracted in a standardised, predefined manner and assessed critically. RESULTS—Seventeen randomised clinical trials were found, six of which concerned the use of traditional Chinese herbal medicine and eight described traditional Indian medicine, of which five investigated Tylophora indica. Three other randomised trials tested a Japanese Kampo medicine, marihuana, and dried ivy leaf extract. Nine of the 17 trials reported a clinically relevant improvement in lung function and/or symptom scores. CONCLUSIONS—No definitive evidence for any of the herbal preparations emerged. Considering the popularity of herbal medicine with asthma patients, there is urgent need for stringently designed clinically relevant randomised clinical trials for herbal preparations in the treatment of asthma.
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- Ammon H. P., Mack T., Singh G. B., Safayhi H. Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata. Planta Med. 1991 Jun;57(3):203–207. doi: 10.1055/s-2006-960074. [DOI] [PubMed] [Google Scholar]
- Bielory L., Lupoli K. Herbal interventions in asthma and allergy. J Asthma. 1999;36(1):1–65. doi: 10.3109/02770909909065150. [DOI] [PubMed] [Google Scholar]
- Doshi V. B., Shetye V. M., Mahashur A. A., Kamat S. R. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med. 1983 Apr;29(2):89–95. [PubMed] [Google Scholar]
- Egashira Y., Nagano H. A multicenter clinical trial of TJ-96 in patients with steroid-dependent bronchial asthma. A comparison of groups allocated by the envelope method. Ann N Y Acad Sci. 1993 Jun 23;685:580–583. doi: 10.1111/j.1749-6632.1993.tb35921.x. [DOI] [PubMed] [Google Scholar]
- Ernst E. Complementary therapies for asthma: what patients use. J Asthma. 1998;35(8):667–671. doi: 10.3109/02770909809048969. [DOI] [PubMed] [Google Scholar]
- Govindan S., Viswanathan S., Vijayasekaran V., Alagappan R. A pilot study on the clinical efficacy of Solanum xanthocarpum and Solanum trilobatum in bronchial asthma. J Ethnopharmacol. 1999 Aug;66(2):205–210. doi: 10.1016/s0378-8741(98)00160-3. [DOI] [PubMed] [Google Scholar]
- Grinspoon L. Marihuana. Sci Am. 1969 Dec;221(6):17–25. doi: 10.1038/scientificamerican1269-17. [DOI] [PubMed] [Google Scholar]
- Gupta I., Gupta V., Parihar A., Gupta S., Lüdtke R., Safayhi H., Ammon H. P. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res. 1998 Nov 17;3(11):511–514. [PubMed] [Google Scholar]
- Gupta S., George P., Gupta V., Tandon V. R., Sundaram K. R. Tylophora indica in bronchial asthma--a double blind study. Indian J Med Res. 1979 Jun;69:981–989. [PubMed] [Google Scholar]
- Jadad A. R., Moore R. A., Carroll D., Jenkinson C., Reynolds D. J., Gavaghan D. J., McQuay H. J. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996 Feb;17(1):1–12. doi: 10.1016/0197-2456(95)00134-4. [DOI] [PubMed] [Google Scholar]
- Shivpuri D. N., Menon M. P., Parkash D. Preliminary studies in Tylophora indica in the treatment of asthma and allergic rhinitis. J Assoc Physicians India. 1968 Jan;16(1):9–15. [PubMed] [Google Scholar]
- Shivpuri D. N., Singhal S. C., Parkash D. Treatment of asthma with an alcoholic extract of tylophora indica: a cross-over, double-blind study. Ann Allergy. 1972 Jul;30(7):407–412. [PubMed] [Google Scholar]
- Tashkin D. P., Shapiro B. J., Frank I. M. Acute pulmonary physiologic effects of smoked marijuana and oral 9 -tetrahydrocannabinol in healthy young men. N Engl J Med. 1973 Aug 16;289(7):336–341. doi: 10.1056/NEJM197308162890702. [DOI] [PubMed] [Google Scholar]
- Thiruvengadam K. V., Haranath K., Sudarsan S., Sekar T. S., Rajagopal K. R., Zacharian M. G., Devarajan T. V. Tylophora indica in bronchial asthma (a controlled comparison with a standard anti-asthmatic drug). J Indian Med Assoc. 1978 Oct 1;71(7):172–176. [PubMed] [Google Scholar]
- Toda S., Kimura M., Ohnishi M., Nakashima K. Effects of the Chinese herbal medicine "saiboku-to" on histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80. J Ethnopharmacol. 1988 Dec;24(2-3):303–309. doi: 10.1016/0378-8741(88)90159-6. [DOI] [PubMed] [Google Scholar]
- Vachon L., FitzGerald M. X., Solliday N. H., Gould I. A., Gaensler E. A. Single-dose effects of marihuana smoke. Bronchial dynamics and respiratory-center sensitivity in normal subjects. N Engl J Med. 1973 May 10;288(19):985–989. doi: 10.1056/NEJM197305102881902. [DOI] [PubMed] [Google Scholar]
- Xu D. S., Shen Z. Y., Wang W. J. [Study on effect of strengthening body resistance method on asthmatic attack]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 Apr;16(4):198–200. [PubMed] [Google Scholar]
- Zou J. P., Gu F. Q., Liao W. J. [Clinical study on treating asthma of cold type with wenyang tongluo mixture]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 Sep;16(9):529–532. [PubMed] [Google Scholar]
