Abstract
BACKGROUND—It is uncertain whether patients with chronic obstructive pulmonary disease (COPD) given oxygen for symptom relief should be advised to use it before or after exertion. METHODS—Eighteen patients with smoking related COPD who desaturated on exercise were given oxygen or air from a cylinder in a single blind manner and in an order determined by Latin square randomisation, before and after ascending stairs. The time of ascent, desaturation, and dyspnoea associated with the ascent was compared across the treatment groups. RESULTS—Oxygen given before or after the ascent reduced maximal dyspnoea from 49.1 mm (95% CI 35.5 to 62.7) to 41.7 mm (95% CI 34.3to 49.1) of a 100 mm visual analogue scale, reduced desaturation (oxygen before 4.9% (95% CI 3.6 to 6.2), oxygen after 6.4% (5.3to 7.5), air before and after 8.2% (6.7 to 9.7%)), but did not affect time of ascent (air before: 5.1 s (95% CI 3.4 to 6.9) reduction from training ascent; oxygen before: 6.1 s (95% CI 2.9 to 9.2) reduction). CONCLUSIONS—Oxygen prescribed for symptomatic relief of dyspnoea benefits selected patients with COPD, but it seems not to matter whether it is taken before or after exertion.
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Selected References
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- Evans T. W., Waterhouse J. C., Carter A., Nicholl J. F., Howard P. Short burst oxygen treatment for breathlessness in chronic obstructive airways disease. Thorax. 1986 Aug;41(8):611–615. doi: 10.1136/thx.41.8.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lane R., Cockcroft A., Adams L., Guz A. Arterial oxygen saturation and breathlessness in patients with chronic obstructive airways disease. Clin Sci (Lond) 1987 Jun;72(6):693–698. doi: 10.1042/cs0720693. [DOI] [PubMed] [Google Scholar]
- McKeon J. L., Murree-Allen K., Saunders N. A. Effects of breathing supplemental oxygen before progressive exercise in patients with chronic obstructive lung disease. Thorax. 1988 Jan;43(1):53–56. doi: 10.1136/thx.43.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts C. M., Bell J., Wedzicha J. A. Comparison of the efficacy of a demand oxygen delivery system with continuous low flow oxygen in subjects with stable COPD and severe oxygen desaturation on walking. Thorax. 1996 Aug;51(8):831–834. doi: 10.1136/thx.51.8.831. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swinburn C. R., Mould H., Stone T. N., Corris P. A., Gibson G. J. Symptomatic benefit of supplemental oxygen in hypoxemic patients with chronic lung disease. Am Rev Respir Dis. 1991 May;143(5 Pt 1):913–915. doi: 10.1164/ajrccm/143.5_Pt_1.913. [DOI] [PubMed] [Google Scholar]
- Swinburn C. R., Wakefield J. M., Jones P. W. Relationship between ventilation and breathlessness during exercise in chronic obstructive airways disease is not altered by prevention of hypoxaemia. Clin Sci (Lond) 1984 Nov;67(5):515–519. doi: 10.1042/cs0670515. [DOI] [PubMed] [Google Scholar]
- Wedzicha J. A. Ambulatory oxygen in chronic obstructive pulmonary disease. Monaldi Arch Chest Dis. 1996 Jun;51(3):243–245. [PubMed] [Google Scholar]
- Woodcock A. A., Gross E. R., Geddes D. M. Oxygen relieves breathlessness in "pink puffers". Lancet. 1981 Apr 25;1(8226):907–909. doi: 10.1016/s0140-6736(81)91612-3. [DOI] [PubMed] [Google Scholar]