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. 1997 Jan;65(1):309–312. doi: 10.1128/iai.65.1.309-312.1997

Interaction of Salmonella typhi strains with cultured human monocyte-derived macrophages.

D R Sizemore 1, E A Elsinghorst 1, L C Eck 1, A A Branstrom 1, D L Hoover 1, R L Warren 1, F A Rubin 1
PMCID: PMC174593  PMID: 8975929

Abstract

Human monocyte-derived macrophages (MDM) provided this laboratory with a tool to develop a primary-cell assay for evaluating the relative virulence of newly constructed Salmonella typhi carrier strains. In this study, the interaction with and survival within MDM were compared for delta aroA143-attenuated strains, wild-type virulent strains, and the current oral-vaccine strain, Ty21a.

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Selected References

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