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. 1997 Jan;65(1):317–319. doi: 10.1128/iai.65.1.317-319.1997

Chlamydia trachomatis major outer membrane protein variants escape neutralization by both monoclonal antibodies and human immune sera.

M F Lampe 1, K G Wong 1, L M Kuehl 1, W E Stamm 1
PMCID: PMC174595  PMID: 8975931

Abstract

We have identified two families of novel Chlamydia trachomatis isolates with amino acid changes within the major outer membrane protein (MOMP) variable domains: one family of Da, D*, and D- and one family of Ia and I-. In order to determine whether these MOMP variants can escape antibody neutralization of infectivity, we tested both the D and I prototype strains and the variants in a complement-independent in vitro neutralization assay. We found that variants can indeed escape neutralization by both monoclonal antibodies and polyclonal human immune sera that neutralize the prototype strain.

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Selected References

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