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. 2001 Dec;56(12):916–923. doi: 10.1136/thorax.56.12.916

Pulmonary 99mTc-DTPA aerosol clearance and survival in usual interstitial pneumonia (UIP)

N Mogulkoc 1, M Brutsche 1, P Bishop 1, B Murby 1, M Greaves 1, A Horrocks 1, M Wilson 1, C McCullough 1, M Prescott 1, J Egan 1
PMCID: PMC1745984  PMID: 11713353

Abstract

BACKGROUND—Clearance of inhaled technetium 99m-labelled diethylenetriamine penta-acetic acid (99mTc-DTPA) from the lungs is a potential indicator of disease progression in patients with idiopathic pulmonary fibrosis (IPF).
METHODS—We prospectively analysed the usefulness of this technique for predicting survival in 106 non-smoking patients with usual interstitial pneumonia (UIP) pattern IPF diagnosed by high resolution CT (HRCT) scanning or histological examination (M/F 65/41, mean (SD) age 61 (11) years). DTPA clearance was analysed according to both mono-exponential and bi-exponential models. Half times for the fast (t0.5F) and slow (t0.5S) components of clearance, the percentage contribution of the fast component (fF), and half time for mono-exponential approximation to the early part of the clearance curve (t0.5) were calculated.
RESULTS—The patients had substantially faster t0.5 (mean 23.9 (9.6) minutes) than normal values (>45 minutes). Thirty seven patients (35%) died during follow up (median 15 months). Univariate Cox regression analysis identified significant predictors of survival as age, forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), total lung capacity (TLC), % predicted TLC, carbon monoxide transfer factor (TLCO), % predicted TLCO, arterial oxygen tension (PaO2), oxygen saturation, t0.5F, and HRCT fibrosis score. Multiple stepwise Cox regression analysis identified t0.5F (p=0.03, hazard ratio 0.747, 95% CI 0.578 to 0.964), % predicted TLC (p=0.02, hazard ratio 0.976, 95% CI 0.956 to 0.995), % predicted TLCO (p=0.003, hazard ratio 0.960, 95% CI 0.935 to 0.986), and age (p=0.003, hazard ratio 1.062, 95% CI 1.021 to 1.104) as independent predictors of survival.
CONCLUSION—These data suggest that 99mTc-DTPA clearance t0.5F measurement may predict survival in patients with UIP pattern IPF.



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Selected References

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