Abstract
BACKGROUND—Exhaled nitric oxide levels are low in patients with cystic fibrosis (CF), despite the chronic inflammation present in the airways. This study aimed to determine whether levels of exhaled nitric oxide were reduced prior to the onset of respiratory symptoms in infants with CF. METHODS—The levels of exhaled nitric oxide were measured using a chemiluminescence analyser in five infants with CF and 11 healthy control subjects, both groups having a mean age of 48.6days. RESULTS—Mean levels of exhaled nitric oxide were significantly lower in infants with CF than in the control group (4.9 ppb v 12.1ppb; p=0.01). CONCLUSIONS—This finding may be the key to understanding the inflammatory processes in early cystic fibrosis and may lead to novel treatment approaches.
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Selected References
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- Ho L. P., Innes J. A., Greening A. P. Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide. Thorax. 1998 Aug;53(8):680–684. doi: 10.1136/thx.53.8.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Khan T. Z., Wagener J. S., Bost T., Martinez J., Accurso F. J., Riches D. W. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med. 1995 Apr;151(4):1075–1082. doi: 10.1164/ajrccm/151.4.1075. [DOI] [PubMed] [Google Scholar]
- Lundberg J. O., Nordvall S. L., Weitzberg E., Kollberg H., Alving K. Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Arch Dis Child. 1996 Oct;75(4):323–326. doi: 10.1136/adc.75.4.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steagall W. K., Elmer H. L., Brady K. G., Kelley T. J. Cystic fibrosis transmembrane conductance regulator-dependent regulation of epithelial inducible nitric oxide synthase expression. Am J Respir Cell Mol Biol. 2000 Jan;22(1):45–50. doi: 10.1165/ajrcmb.22.1.3789. [DOI] [PubMed] [Google Scholar]