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. 2001 Jun;56(6):427–431. doi: 10.1136/thorax.56.6.427

Dendritic cells in the mucosa of the human trachea are not regularly found in the first year of life

T Tschernig 1, A Debertin 1, F Paulsen 1, W Kleemann 1, R Pabst 1
PMCID: PMC1746069  PMID: 11359956

Abstract

BACKGROUND—Dendritic cells (DCs) in the mucosa of the respiratory tract might be involved in the early development of pulmonary allergy or tolerance. To date, little is known about when the first DCs occur in human airways.
METHODS—Specimens of the distal trachea from patients who had died from sudden death in the first year of life (n=29) and in older age groups (n=59) as well as from those who had died from respiratory tract infections in the first year of life (n=8) were examined by immunohistochemistry. Transmission electron microscopy was performed in additional samples from two adults.
RESULTS—In the sudden death subgroup DCs were absent in 76% of those who died in the first year of life but were present in 53 of the 59 older cases. All infants who had died of respiratory infectious diseases had DCs in the tracheal mucosa.
CONCLUSIONS—Mature DCs are not constitutively present in the human tracheobronchial mucosa in the first year of life, but their occurrence seems to be triggered by infectious stimuli. These data support the hypothesis that DCs play a crucial role in immunoregulation in early childhood.



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Selected References

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  1. Bottomly K. T cells and dendritic cells get intimate. Science. 1999 Feb 19;283(5405):1124–1125. doi: 10.1126/science.283.5405.1124. [DOI] [PubMed] [Google Scholar]
  2. Cochand L., Isler P., Songeon F., Nicod L. P. Human lung dendritic cells have an immature phenotype with efficient mannose receptors. Am J Respir Cell Mol Biol. 1999 Nov;21(5):547–554. doi: 10.1165/ajrcmb.21.5.3785. [DOI] [PubMed] [Google Scholar]
  3. Fearnley D. B., Whyte L. F., Carnoutsos S. A., Cook A. H., Hart D. N. Monitoring human blood dendritic cell numbers in normal individuals and in stem cell transplantation. Blood. 1999 Jan 15;93(2):728–736. [PubMed] [Google Scholar]
  4. Folkerts G., Walzl G., Openshaw P. J. Do common childhood infections 'teach' the immune system not to be allergic? Immunol Today. 2000 Mar;21(3):118–120. doi: 10.1016/s0167-5699(00)01582-6. [DOI] [PubMed] [Google Scholar]
  5. Fu Y. X., Chaplin D. D. Development and maturation of secondary lymphoid tissues. Annu Rev Immunol. 1999;17:399–433. doi: 10.1146/annurev.immunol.17.1.399. [DOI] [PubMed] [Google Scholar]
  6. Gong J. L., McCarthy K. M., Telford J., Tamatani T., Miyasaka M., Schneeberger E. E. Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection. J Exp Med. 1992 Mar 1;175(3):797–807. doi: 10.1084/jem.175.3.797. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hamada K., Goldsmith C. A., Goldman A., Kobzik L. Resistance of very young mice to inhaled allergen sensitization is overcome by coexposure to an air-pollutant aerosol. Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1285–1293. doi: 10.1164/ajrccm.161.4.9906137. [DOI] [PubMed] [Google Scholar]
  8. Hiller A. S., Tschernig T., Kleemann W. J., Pabst R. Bronchus-associated lymphoid tissue (BALT) and larynx-associated lymphoid tissue (LALT) are found at different frequencies in children, adolescents and adults. Scand J Immunol. 1998 Feb;47(2):159–162. doi: 10.1046/j.1365-3083.1998.00276.x. [DOI] [PubMed] [Google Scholar]
  9. Holt P. G. Antigen presentation in the lung. Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 2):S151–S156. doi: 10.1164/ajrccm.162.supplement_3.15tac2. [DOI] [PubMed] [Google Scholar]
  10. Holt P. G., Jones C. A. The development of the immune system during pregnancy and early life. Allergy. 2000 Aug;55(8):688–697. doi: 10.1034/j.1398-9995.2000.00118.x. [DOI] [PubMed] [Google Scholar]
  11. Holt P. G., Macaubas C., Prescott S. L., Sly P. D. Primary sensitization to inhalant allergens. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 2):S91–S94. doi: 10.1164/ajrccm.162.supplement_2.ras-7. [DOI] [PubMed] [Google Scholar]
  12. Holt P. G., Sly P. D. Prevention of adult asthma by early intervention during childhood: potential value of new generation immunomodulatory drugs. Thorax. 2000 Aug;55(8):700–703. doi: 10.1136/thorax.55.8.700. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hoogsteden H. C., Verhoeven G. T., Lambrecht B. N., Prins J. B. Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen-presenting dendritic cell: influence of treatment with fluticasone propionate. Clin Exp Allergy. 1999 Jun;29 (Suppl 2):116–124. doi: 10.1046/j.1365-2222.1999.00020.x. [DOI] [PubMed] [Google Scholar]
  14. Jecker P., McWilliam A., Napoli S., Holt P. G., Pabst R., Westhofen M., Westermann J. Acute laryngitis in the rat induced by Moraxella catarrhalis and Bordetella pertussis: number of neutrophils, dendritic cells, and T and B lymphocytes accumulating during infection in the laryngeal mucosa strongly differs in adjacent locations. Pediatr Res. 1999 Dec;46(6):760–766. doi: 10.1203/00006450-199912000-00020. [DOI] [PubMed] [Google Scholar]
  15. Kapsenberg M. L., Hilkens C. M., Wierenga E. A., Kalinski P. The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy. Clin Exp Allergy. 1999 Jun;29 (Suppl 2):33–36. [PubMed] [Google Scholar]
  16. Lambrecht B. N., Salomon B., Klatzmann D., Pauwels R. A. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J Immunol. 1998 Apr 15;160(8):4090–4097. [PubMed] [Google Scholar]
  17. MacPherson G. G., Liu L. M. Dendritic cells and Langerhans cells in the uptake of mucosal antigens. Curr Top Microbiol Immunol. 1999;236:33–53. doi: 10.1007/978-3-642-59951-4_3. [DOI] [PubMed] [Google Scholar]
  18. Marshall-Clarke S., Reen D., Tasker L., Hassan J. Neonatal immunity: how well has it grown up? Immunol Today. 2000 Jan;21(1):35–41. doi: 10.1016/s0167-5699(99)01548-0. [DOI] [PubMed] [Google Scholar]
  19. Martinez F. D. Viruses and atopic sensitization in the first years of life. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 2):S95–S99. doi: 10.1164/ajrccm.162.supplement_2.ras-8. [DOI] [PubMed] [Google Scholar]
  20. McWilliam A. S., Holt P. G. Immunobiology of dendritic cells in the respiratory tract: steady-state and inflammatory sentinels? Toxicol Lett. 1998 Dec 28;102-103:323–329. doi: 10.1016/s0378-4274(98)00326-9. [DOI] [PubMed] [Google Scholar]
  21. McWilliam A. S., Marsh A. M., Holt P. G. Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: involvement of epithelial dendritic cells. J Virol. 1997 Jan;71(1):226–236. doi: 10.1128/jvi.71.1.226-236.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. McWilliam A. S., Nelson D., Thomas J. A., Holt P. G. Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces. J Exp Med. 1994 Apr 1;179(4):1331–1336. doi: 10.1084/jem.179.4.1331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Möller G. M., Overbeek S. E., Van Helden-Meeuwsen C. G., Van Haarst J. M., Prens E. P., Mulder P. G., Postma D. S., Hoogsteden H. C. Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids. Clin Exp Allergy. 1996 May;26(5):517–524. [PubMed] [Google Scholar]
  24. Nelson D. J., McMenamin C., McWilliam A. S., Brenan M., Holt P. G. Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract. J Exp Med. 1994 Jan 1;179(1):203–212. doi: 10.1084/jem.179.1.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Okato S., Magari S., Yamamoto Y., Sakanaka M., Takahashi H. An immuno-electron microscopic study on interactions among dendritic cells, macrophages and lymphocytes in the human palatine tonsil. Arch Histol Cytol. 1989 Jul;52(3):231–240. doi: 10.1679/aohc.52.231. [DOI] [PubMed] [Google Scholar]
  26. Paulsen F., Tillmann B. Composition of the extracellular matrix in human cricoarytenoid joint articular cartilage. Arch Histol Cytol. 1999 May;62(2):149–163. doi: 10.1679/aohc.62.149. [DOI] [PubMed] [Google Scholar]
  27. Prescott S. L., Macaubes C., Yabuhara A., Venaille T. J., Holt B. J., Habre W., Loh R., Sly P. D., Holt P. G. Developing patterns of T cell memory to environmental allergens in the first two years of life. Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):75–79. doi: 10.1159/000237512. [DOI] [PubMed] [Google Scholar]
  28. Reischl I. G. Dendritic cells and lung antigen responses. Clin Exp Allergy. 2000 Feb;30(2):160–163. doi: 10.1046/j.1365-2222.2000.00720.x. [DOI] [PubMed] [Google Scholar]
  29. Reynolds H. Y. Advances in understanding pulmonary host defense mechanisms: dendritic cell function and immunomodulation. Curr Opin Pulm Med. 2000 May;6(3):209–216. doi: 10.1097/00063198-200005000-00008. [DOI] [PubMed] [Google Scholar]
  30. Sly PD. Introduction. Thorax. 2000 Jul;55(7):585–586. doi: 10.1136/thorax.55.7.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Steinman R. M., Inaba K. Myeloid dendritic cells. J Leukoc Biol. 1999 Aug;66(2):205–208. doi: 10.1002/jlb.66.2.205. [DOI] [PubMed] [Google Scholar]
  32. Stick S. Pediatric origins of adult lung disease. 1. The contribution of airway development to paediatric and adult lung disease. Thorax. 2000 Jul;55(7):587–594. doi: 10.1136/thorax.55.7.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Stumbles P. A., Thomas J. A., Pimm C. L., Lee P. T., Venaille T. J., Proksch S., Holt P. G. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J Exp Med. 1998 Dec 7;188(11):2019–2031. doi: 10.1084/jem.188.11.2019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Yabuhara A., Macaubas C., Prescott S. L., Venaille T. J., Holt B. J., Habre W., Sly P. D., Holt P. G. TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood. Clin Exp Allergy. 1997 Nov;27(11):1261–1269. [PubMed] [Google Scholar]

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