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. 2001 Jul;56(7):536–540. doi: 10.1136/thorax.56.7.536

Effect of gas cooking on lung function in adolescents: modifying role of sex and immunoglobulin E

G Corbo 1, F Forastiere 1, N Agabiti 1, V Dell'Orco 1, R Pistelli 1, M Aebischer 1, S Valente 1, C Perucci 1
PMCID: PMC1746100  PMID: 11413352

Abstract

BACKGROUND—A study was undertaken to investigate the effect of gas cooking on the lung function of adolescents while considering serum IgE level as a possible effect modifier.
METHOD—The cross sectional study was performed in 702 subjects aged 11-13 years from primary and secondary schools in Civitavecchia and Viterbo ( Latium region in Central Italy), categorised according to how often they were in the kitchen while the mother cooked (never, sometimes, often). Data were collected by questionnaire and lung function was measured by spirometric tests. Bronchial hyperresponsiveness was evaluated by the methacholine test, atopic status by a skin prick test, and a blood sample was collected to determine serum IgE levels. The results were analysed separately for boys and girls. Multiple regression analysis was performed, taking functional parameters (FEV1, FEV1/FVC, FEF25-75, FEF50, FEF75) as the dependent variables and age, height, parental smoking, and father's education as independent variables.
RESULTS—There was no association between time spent in the kitchen and lung function level in boys, but a reduction in lung function was detected in girls which was statistically significant for FEF75 (sometimes -10.3%, often -11.1%). After stratifying boys and girls into four groups on the basis of the IgE serum level (below and above the median value of IgE), the reduction in lung function was significant in girls with a high IgE value whereas no significant deleterious effects were evident in girls with a low IgE value or in boys with either a low or high IgE. The results remained substantially unchanged after excluding girls with a response to methacholine below the concentration of 4 mg/ml, asthmatic patients, and those with positive skin prick tests.
CONCLUSION—Gas cooking has a harmful effect on the lung function of girls with a high serum level of IgE. We do not know whether serum IgE, a marker of allergic susceptibility, is a simple indicator that an inflammatory process is in progress or whether it is involved in the pathogenesis of injury leading to bronchial obstruction.



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Selected References

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  1. Colloff M. J., Ayres J., Carswell F., Howarth P. H., Merrett T. G., Mitchell E. B., Walshaw M. J., Warner J. O., Warner J. A., Woodcock A. A. The control of allergens of dust mites and domestic pets: a position paper. Clin Exp Allergy. 1992 Sep;22 (Suppl 2):1–28. doi: 10.1111/j.1365-2222.1992.tb01763.x. [DOI] [PubMed] [Google Scholar]
  2. Dell'Orco V., Forastiere F., Agabiti N., Corbo G. M., Pistelli R., Pacifici R., Zuccaro P., Pizzabiocca A., Rosa M., Altieri I. Household and community determinants of exposure to involuntary smoking: a study of urinary cotinine in children and adolescents. Am J Epidemiol. 1995 Aug 15;142(4):419–427. doi: 10.1093/oxfordjournals.aje.a117650. [DOI] [PubMed] [Google Scholar]
  3. Demissie K., Ernst P., Joseph L., Becklake M. R. The role of domestic factors and day-care attendance on lung function of primary school children. Respir Med. 1998 Jul;92(7):928–935. doi: 10.1016/s0954-6111(98)90192-5. [DOI] [PubMed] [Google Scholar]
  4. Devalia J. L., Campbell A. M., Sapsford R. J., Rusznak C., Quint D., Godard P., Bousquet J., Davies R. J. Effect of nitrogen dioxide on synthesis of inflammatory cytokines expressed by human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol. 1993 Sep;9(3):271–278. doi: 10.1165/ajrcmb/9.3.271. [DOI] [PubMed] [Google Scholar]
  5. Garrett M. H., Hooper M. A., Hooper B. M., Abramson M. J. Respiratory symptoms in children and indoor exposure to nitrogen dioxide and gas stoves. Am J Respir Crit Care Med. 1998 Sep;158(3):891–895. doi: 10.1164/ajrccm.158.3.9701084. [DOI] [PubMed] [Google Scholar]
  6. Hasselblad V., Eddy D. M., Kotchmar D. J. Synthesis of environmental evidence: nitrogen dioxide epidemiology studies. J Air Waste Manage Assoc. 1992 May;42(5):662–671. doi: 10.1080/10473289.1992.10467018. [DOI] [PubMed] [Google Scholar]
  7. Jarvis D., Chinn S., Luczynska C., Burney P. Association of respiratory symptoms and lung function in young adults with use of domestic gas appliances. Lancet. 1996 Feb 17;347(8999):426–431. doi: 10.1016/s0140-6736(96)90009-4. [DOI] [PubMed] [Google Scholar]
  8. Jarvis D., Chinn S., Sterne J., Luczynska C., Burney P. The association of respiratory symptoms and lung function with the use of gas for cooking. European Community Respiratory Health Survey. Eur Respir J. 1998 Mar;11(3):651–658. [PubMed] [Google Scholar]
  9. Kerkhof M., de Monchy J. G., Rijken B., Schouten J. P. The effect of gas cooking on bronchial hyperresponsiveness and the role of immunoglobulin E. Eur Respir J. 1999 Oct;14(4):839–844. doi: 10.1034/j.1399-3003.1999.14d20.x. [DOI] [PubMed] [Google Scholar]
  10. Landau L. I., Morgan W., McCoy K. S., Taussig L. M. Gender related differences in airway tone in children. Pediatr Pulmonol. 1993 Jul;16(1):31–35. doi: 10.1002/ppul.1950160107. [DOI] [PubMed] [Google Scholar]
  11. Melia R. J., Florey C. D., Altman D. G., Swan A. V. Association between gas cooking and respiratory disease in children. Br Med J. 1977 Jul 16;2(6080):149–152. doi: 10.1136/bmj.2.6080.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Moran S. E., Strachan D. P., Johnston I. D., Anderson H. R. Effects of exposure to gas cooking in childhood and adulthood on respiratory symptoms, allergic sensitization and lung function in young British adults. Clin Exp Allergy. 1999 Aug;29(8):1033–1041. doi: 10.1046/j.1365-2222.1999.00561.x. [DOI] [PubMed] [Google Scholar]
  13. Neas L. M., Dockery D. W., Ware J. H., Spengler J. D., Speizer F. E., Ferris B. G., Jr Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children. Am J Epidemiol. 1991 Jul 15;134(2):204–219. doi: 10.1093/oxfordjournals.aje.a116073. [DOI] [PubMed] [Google Scholar]
  14. Pershagen G., Rylander E., Norberg S., Eriksson M., Nordvall S. L. Air pollution involving nitrogen dioxide exposure and wheezing bronchitis in children. Int J Epidemiol. 1995 Dec;24(6):1147–1153. doi: 10.1093/ije/24.6.1147. [DOI] [PubMed] [Google Scholar]
  15. Samet J. M., Lambert W. E., Skipper B. J., Cushing A. H., Hunt W. C., Young S. A., McLaren L. C., Schwab M., Spengler J. D. Nitrogen dioxide and respiratory illnesses in infants. Am Rev Respir Dis. 1993 Nov;148(5):1258–1265. doi: 10.1164/ajrccm/148.5.1258. [DOI] [PubMed] [Google Scholar]
  16. Speizer F. E., Ferris B., Jr, Bishop Y. M., Spengler J. Respiratory disease rates and pulmonary function in children associated with NO2 exposure. Am Rev Respir Dis. 1980 Jan;121(1):3–10. doi: 10.1164/arrd.1980.121.1.3. [DOI] [PubMed] [Google Scholar]
  17. Strand V., Salomonsson P., Lundahl J., Bylin G. Immediate and delayed effects of nitrogen dioxide exposure at an ambient level on bronchial responsiveness to histamine in subjects with asthma. Eur Respir J. 1996 Apr;9(4):733–740. doi: 10.1183/09031936.96.09040733. [DOI] [PubMed] [Google Scholar]
  18. Tunnicliffe W. S., Burge P. S., Ayres J. G. Effect of domestic concentrations of nitrogen dioxide on airway responses to inhaled allergen in asthmatic patients. Lancet. 1994 Dec 24;344(8939-8940):1733–1736. doi: 10.1016/s0140-6736(94)92886-x. [DOI] [PubMed] [Google Scholar]
  19. Ware J. H., Dockery D. W., Spiro A., 3rd, Speizer F. E., Ferris B. G., Jr Passive smoking, gas cooking, and respiratory health of children living in six cities. Am Rev Respir Dis. 1984 Mar;129(3):366–374. doi: 10.1164/arrd.1984.129.3.366. [DOI] [PubMed] [Google Scholar]

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