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. 2002 Jan;57(1):45–49. doi: 10.1136/thorax.57.1.45

Screening for tuberculosis: the port of arrival scheme compared with screening in general practice and the homeless

G Bothamley 1, J Rowan 1, C Griffiths 1, M Beeks 1, M McDonald 1, E Beasley 1, C van den Bosch 1, G Feder 1
PMCID: PMC1746167  PMID: 11809989

Abstract

Background: Tuberculosis is increasing in London, especially in those recently entering the UK from an area of high incidence. Screening through the port of arrival scheme has a poor yield and has been considered discriminatory.

Methods: A study was undertaken to compare the yield and costs of screening new entrants in a hospital based new entrants' clinic (1262 referrals from the port of arrival), general practice (1311 new registrations), and centres for the homeless (267 individuals) using a symptom questionnaire and tuberculin testing if indicated. Clinical outcome measures were cases of tuberculosis, tuberculin reactors requiring chemoprophylaxis and BCG vaccinations. Cost outcomes were cost per individual screened and cost per individual per case of tuberculosis prevented.

Results: Verbal screening limited tuberculin testing to 16% of those in general practice; most were tested at the other two locations. Intervention (BCG vaccination, chemoprophylaxis or treatment) occurred in 27% of those who received tuberculin testing. Attendance for screening was 17% of the port of arrival notifications (63% had registered with a GP), 54% in primary care, and 67% in the homeless (42% registered with a GP). Costs for screening an individual in general practice, hostels for the homeless, and the new entrants' clinic were £1.26, £13.17 and £96.36, respectively, while the cost per person screened per case of tuberculosis prevented was £6.32, £23.00, and £10.00, respectively. The benefit of screening was highly sensitive to the number of cases of tuberculosis identified and case holding during treatment.

Conclusion: Screening for tuberculosis in primary care is feasible and could replace hospital screening of new arrivals for those registered with a GP.

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Selected References

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  1. Bakhshi S. Screening immigrants at risk of tuberculosis. BMJ. 1994 Feb 5;308(6925):416–416. doi: 10.1136/bmj.308.6925.416a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blower S. M., McLean A. R., Porco T. C., Small P. M., Hopewell P. C., Sanchez M. A., Moss A. R. The intrinsic transmission dynamics of tuberculosis epidemics. Nat Med. 1995 Aug;1(8):815–821. doi: 10.1038/nm0895-815. [DOI] [PubMed] [Google Scholar]
  3. Bowen E. F., Rice P. S., Cooke N. T., Whitfield R. J., Rayner C. F. HIV seroprevalence by anonymous testing in patients with Mycobacterium tuberculosis and in tuberculosis contacts. Lancet. 2000 Oct 28;356(9240):1488–1489. doi: 10.1016/S0140-6736(00)02876-2. [DOI] [PubMed] [Google Scholar]
  4. Chaparas S. D., Vandiviere H. M., Melvin I., Koch G., Becker C. Tuberculin test. Variability with the Mantoux procedure. Am Rev Respir Dis. 1985 Jul;132(1):175–177. doi: 10.1164/arrd.1985.132.1.175. [DOI] [PubMed] [Google Scholar]
  5. Citron K. M. Control and prevention of tuberculosis in Britain. Br Med Bull. 1988 Jul;44(3):704–716. doi: 10.1093/oxfordjournals.bmb.a072278. [DOI] [PubMed] [Google Scholar]
  6. Comstock G. W., Livesay V. T., Woolpert S. F. The prognosis of a positive tuberculin reaction in childhood and adolescence. Am J Epidemiol. 1974 Feb;99(2):131–138. doi: 10.1093/oxfordjournals.aje.a121593. [DOI] [PubMed] [Google Scholar]
  7. Ferebee S. H. Controlled chemoprophylaxis trials in tuberculosis. A general review. Bibl Tuberc. 1970;26:28–106. [PubMed] [Google Scholar]
  8. Ferebee S. H. Controlled chemoprophylaxis trials in tuberculosis. A general review. Bibl Tuberc. 1970;26:28–106. [PubMed] [Google Scholar]
  9. Griffiths C., Cooke S., Toon P. Registration health checks: inverse care in the inner city? Br J Gen Pract. 1994 May;44(382):201–204. [PMC free article] [PubMed] [Google Scholar]
  10. Hardie R. M., Watson J. M. Screening migrants at risk of tuberculosis. BMJ. 1993 Dec 11;307(6918):1539–1540. doi: 10.1136/bmj.307.6918.1539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kumar D., Watson J. M., Charlett A., Nicholas S., Darbyshire J. H. Tuberculosis in England and Wales in 1993: results of a national survey. Public Health Laboratory Service/British Thoracic Society/Department of Health Collaborative Group. Thorax. 1997 Dec;52(12):1060–1067. doi: 10.1136/thx.52.12.1060. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lobato M. N., Hopewell P. C. Mycobacterium tuberculosis infection after travel to or contact with visitors from countries with a high prevalence of tuberculosis. Am J Respir Crit Care Med. 1998 Dec;158(6):1871–1875. doi: 10.1164/ajrccm.158.6.9804106. [DOI] [PubMed] [Google Scholar]
  13. Moore R. D., Chaulk C. P., Griffiths R., Cavalcante S., Chaisson R. E. Cost-effectiveness of directly observed versus self-administered therapy for tuberculosis. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1013–1019. doi: 10.1164/ajrccm.154.4.8887600. [DOI] [PubMed] [Google Scholar]
  14. Morris J. A., Gardner M. J. Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates. Br Med J (Clin Res Ed) 1988 May 7;296(6632):1313–1316. doi: 10.1136/bmj.296.6632.1313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Murray C. J., DeJonghe E., Chum H. J., Nyangulu D. S., Salomao A., Styblo K. Cost effectiveness of chemotherapy for pulmonary tuberculosis in three sub-Saharan African countries. Lancet. 1991 Nov 23;338(8778):1305–1308. doi: 10.1016/0140-6736(91)92600-7. [DOI] [PubMed] [Google Scholar]
  16. Ormerod L. P. Tuberculosis screening and prevention in new immigrants 1983-88. Respir Med. 1990 Jul;84(4):269–271. doi: 10.1016/s0954-6111(08)80051-0. [DOI] [PubMed] [Google Scholar]
  17. Selwyn P. A., Hartel D., Lewis V. A., Schoenbaum E. E., Vermund S. H., Klein R. S., Walker A. T., Friedland G. H. A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection. N Engl J Med. 1989 Mar 2;320(9):545–550. doi: 10.1056/NEJM198903023200901. [DOI] [PubMed] [Google Scholar]
  18. White V. L., Moore-Gillon J. Resource implications of patients with multidrug resistant tuberculosis. Thorax. 2000 Nov;55(11):962–963. doi: 10.1136/thorax.55.11.962. [DOI] [PMC free article] [PubMed] [Google Scholar]

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