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. 2002 Jun;57(6):483–488. doi: 10.1136/thorax.57.6.483

Independent validation of the Sleep Apnoea Quality of Life Index

Y Lacasse 1, C Godbout 1, F Series 1
PMCID: PMC1746356  PMID: 12037222

Abstract

Background: Obstructive sleep apnoea (OSA) affects important domains of quality of life which remain unexplored by conventional sleep recordings. The objective of this study was to examine the measurement properties (both discriminative and evaluative) of the Sleep Apnoea Quality of Life Index (SAQLI), a new OSA specific quality of life questionnaire.

Methods: Consecutive patients recently diagnosed with OSA completed a French version of the SAQLI twice over a 3 month period. Its construct validity and responsiveness were tested by comparing baseline and change scores obtained in each domain (symptoms, activities, emotions, social interactions) with those of questionnaires measuring related constructs (SF-36, Epworth Scale, Beck Depression Inventory, and Symptom Checklist 90). The symptoms scores were also correlated with physiological measures obtained at baseline polysomnographic recording.

Results: Forty seven patients (40 men) of mean (SD) age 53 (10) years and mean (SD) apnoea/hypopnoea index 38 (21) participated in the study. During the study period 33 of the 47 patients were treated for OSA (31 with nasal CPAP, one with uvulopalatopharyngoplasty, and one with an oral appliance). Moderate to high correlations were found between the scores in each domain of the SAQLI and the corresponding instruments. There were significant differences in change scores between patients who were treated and those who were not, moderate correlations between SAQLI change scores and changes in the corresponding instruments, and no correlation between the symptoms scores and the baseline nocturnal features. Most of these correlations met the a priori predictions made regarding their magnitude.

Conclusion: The SAQLI has strong construct validity and is responsive to change in quality of life but has the disadvantage of having to be administered by an interviewer.

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Selected References

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  1. BECK A. T., WARD C. H., MENDELSON M., MOCK J., ERBAUGH J. An inventory for measuring depression. Arch Gen Psychiatry. 1961 Jun;4:561–571. doi: 10.1001/archpsyc.1961.01710120031004. [DOI] [PubMed] [Google Scholar]
  2. Block A. J., Boysen P. G., Wynne J. W., Hunt L. A. Sleep apnea, hypopnea and oxygen desaturation in normal subjects. A strong male predominance. N Engl J Med. 1979 Mar 8;300(10):513–517. doi: 10.1056/NEJM197903083001001. [DOI] [PubMed] [Google Scholar]
  3. D'Ambrosio C., Bowman T., Mohsenin V. Quality of life in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure--a prospective study. Chest. 1999 Jan;115(1):123–129. doi: 10.1378/chest.115.1.123. [DOI] [PubMed] [Google Scholar]
  4. Davis J. A., Fine E. D., Maniglia A. J. Uvulopalatopharyngoplasty for obstructive sleep apnea in adults: clinical correlation with polysomnographic results. Ear Nose Throat J. 1993 Jan;72(1):63–66. [PubMed] [Google Scholar]
  5. Engleman H. M., Kingshott R. N., Wraith P. K., Mackay T. W., Deary I. J., Douglas N. J. Randomized placebo-controlled crossover trial of continuous positive airway pressure for mild sleep Apnea/Hypopnea syndrome. Am J Respir Crit Care Med. 1999 Feb;159(2):461–467. doi: 10.1164/ajrccm.159.2.9803121. [DOI] [PubMed] [Google Scholar]
  6. Flemons W. W., Reimer M. A. Development of a disease-specific health-related quality of life questionnaire for sleep apnea. Am J Respir Crit Care Med. 1998 Aug;158(2):494–503. doi: 10.1164/ajrccm.158.2.9712036. [DOI] [PubMed] [Google Scholar]
  7. Guillemin F., Bombardier C., Beaton D. Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. J Clin Epidemiol. 1993 Dec;46(12):1417–1432. doi: 10.1016/0895-4356(93)90142-n. [DOI] [PubMed] [Google Scholar]
  8. Guyatt G. H., Bombardier C., Tugwell P. X. Measuring disease-specific quality of life in clinical trials. CMAJ. 1986 Apr 15;134(8):889–895. [PMC free article] [PubMed] [Google Scholar]
  9. Guyatt G. H., Feeny D. H., Patrick D. L. Measuring health-related quality of life. Ann Intern Med. 1993 Apr 15;118(8):622–629. doi: 10.7326/0003-4819-118-8-199304150-00009. [DOI] [PubMed] [Google Scholar]
  10. Guyatt G. H., Thompson P. J., Berman L. B., Sullivan M. J., Townsend M., Jones N. L., Pugsley S. O. How should we measure function in patients with chronic heart and lung disease? J Chronic Dis. 1985;38(6):517–524. doi: 10.1016/0021-9681(85)90035-9. [DOI] [PubMed] [Google Scholar]
  11. Jaeschke R., Singer J., Guyatt G. H. Measurement of health status. Ascertaining the minimal clinically important difference. Control Clin Trials. 1989 Dec;10(4):407–415. doi: 10.1016/0197-2456(89)90005-6. [DOI] [PubMed] [Google Scholar]
  12. Johns M. W. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540–545. doi: 10.1093/sleep/14.6.540. [DOI] [PubMed] [Google Scholar]
  13. Jones P. W. Testing health status ("quality of life") questionnaires for asthma and COPD. Eur Respir J. 1998 Jan;11(1):5–6. doi: 10.1183/09031936.98.11010005. [DOI] [PubMed] [Google Scholar]
  14. Juniper E. F., Buist A. S., Cox F. M., Ferrie P. J., King D. R. Validation of a standardized version of the Asthma Quality of Life Questionnaire. Chest. 1999 May;115(5):1265–1270. doi: 10.1378/chest.115.5.1265. [DOI] [PubMed] [Google Scholar]
  15. Juniper E. F., Guyatt G. H., Ferrie P. J., Griffith L. E. Measuring quality of life in asthma. Am Rev Respir Dis. 1993 Apr;147(4):832–838. doi: 10.1164/ajrccm/147.4.832. [DOI] [PubMed] [Google Scholar]
  16. Kramer M. S., Feinstein A. R. Clinical biostatistics. LIV. The biostatistics of concordance. Clin Pharmacol Ther. 1981 Jan;29(1):111–123. doi: 10.1038/clpt.1981.18. [DOI] [PubMed] [Google Scholar]
  17. Lacasse Y., Godbout C., Sériès F. Health-related quality of life in obstructive sleep apnoea. Eur Respir J. 2002 Mar;19(3):499–503. doi: 10.1183/09031936.02.00216902. [DOI] [PubMed] [Google Scholar]
  18. Leplège A., Ecosse E., Verdier A., Perneger T. V. The French SF-36 Health Survey: translation, cultural adaptation and preliminary psychometric evaluation. J Clin Epidemiol. 1998 Nov;51(11):1013–1023. doi: 10.1016/s0895-4356(98)00093-6. [DOI] [PubMed] [Google Scholar]
  19. McHorney C. A., Ware J. E., Jr, Raczek A. E. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993 Mar;31(3):247–263. doi: 10.1097/00005650-199303000-00006. [DOI] [PubMed] [Google Scholar]
  20. Weaver T. E., Laizner A. M., Evans L. K., Maislin G., Chugh D. K., Lyon K., Smith P. L., Schwartz A. R., Redline S., Pack A. I. An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep. 1997 Oct;20(10):835–843. [PubMed] [Google Scholar]
  21. Wright J., Johns R., Watt I., Melville A., Sheldon T. Health effects of obstructive sleep apnoea and the effectiveness of continuous positive airways pressure: a systematic review of the research evidence. BMJ. 1997 Mar 22;314(7084):851–860. doi: 10.1136/bmj.314.7084.851. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Young T., Palta M., Dempsey J., Skatrud J., Weber S., Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993 Apr 29;328(17):1230–1235. doi: 10.1056/NEJM199304293281704. [DOI] [PubMed] [Google Scholar]

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