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. 2003 Oct;58(10):867–871. doi: 10.1136/thorax.58.10.867

Domiciliary non-invasive ventilation for recurrent acidotic exacerbations of COPD: an economic analysis

J Tuggey 1, P Plant 1, M Elliott 1
PMCID: PMC1746494  PMID: 14514940

Abstract

Methods: A cost and consequences analysis of domiciliary NIV based on a before and after case note audit was performed in patients with recurrent acidotic exacerbations of COPD who tolerated and responded well to NIV. The primary outcome measure was the total cost incurred per patient per year from the perspective of the acute hospital. Effectiveness outcomes were total days in hospital and in intensive care.

Results: Thirteen patients were identified. Provision of a home NIV service resulted in a mean (95% CI) saving of £8254 (£4013 to £12 495) (€11 720; €5698 to €17 743) per patient per year. Total days in hospital fell from a mean (SD) of 78 (51) to 25 (25) (p=0.004), number of admissions from 5 (3) to 2 (2) (p=0.007), and ICU days fell from a total of 25 to 4 (p=0.24). Outpatient visits fell from a mean of 5 (3) to 4 (2) (p=0.14).

Conclusions: This study suggests that domiciliary NIV for a highly selected group of COPD patients with recurrent admissions requiring NIV is effective at reducing admissions and minimises costs from the perspective of the acute hospital. Such evidence is important in obtaining financial support for providing such a service.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Angus R. M., Ahmed A. A., Fenwick L. J., Peacock A. J. Comparison of the acute effects on gas exchange of nasal ventilation and doxapram in exacerbations of chronic obstructive pulmonary disease. Thorax. 1996 Oct;51(10):1048–1050. doi: 10.1136/thx.51.10.1048. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bott J., Carroll M. P., Conway J. H., Keilty S. E., Ward E. M., Brown A. M., Paul E. A., Elliott M. W., Godfrey R. C., Wedzicha J. A. Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease. Lancet. 1993 Jun 19;341(8860):1555–1557. doi: 10.1016/0140-6736(93)90696-e. [DOI] [PubMed] [Google Scholar]
  3. Brochard L., Mancebo J., Wysocki M., Lofaso F., Conti G., Rauss A., Simonneau G., Benito S., Gasparetto A., Lemaire F. Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med. 1995 Sep 28;333(13):817–822. doi: 10.1056/NEJM199509283331301. [DOI] [PubMed] [Google Scholar]
  4. Casanova C., Celli B. R., Tost L., Soriano E., Abreu J., Velasco V., Santolaria F. Long-term controlled trial of nocturnal nasal positive pressure ventilation in patients with severe COPD. Chest. 2000 Dec;118(6):1582–1590. doi: 10.1378/chest.118.6.1582. [DOI] [PubMed] [Google Scholar]
  5. Celikel T., Sungur M., Ceyhan B., Karakurt S. Comparison of noninvasive positive pressure ventilation with standard medical therapy in hypercapnic acute respiratory failure. Chest. 1998 Dec;114(6):1636–1642. doi: 10.1378/chest.114.6.1636. [DOI] [PubMed] [Google Scholar]
  6. Clini E., Sturani C., Rossi A., Viaggi S., Corrado A., Donner C. F., Ambrosino N., Rehabilitation and Chronic Care Study Group, Italian Association of Hospital Pulmonologists (AIPO) The Italian multicentre study on noninvasive ventilation in chronic obstructive pulmonary disease patients. Eur Respir J. 2002 Sep;20(3):529–538. doi: 10.1183/09031936.02.02162001. [DOI] [PubMed] [Google Scholar]
  7. Jones S. E., Packham S., Hebden M., Smith A. P. Domiciliary nocturnal intermittent positive pressure ventilation in patients with respiratory failure due to severe COPD: long-term follow up and effect on survival. Thorax. 1998 Jun;53(6):495–498. doi: 10.1136/thx.53.6.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kramer N., Meyer T. J., Meharg J., Cece R. D., Hill N. S. Randomized, prospective trial of noninvasive positive pressure ventilation in acute respiratory failure. Am J Respir Crit Care Med. 1995 Jun;151(6):1799–1806. doi: 10.1164/ajrccm.151.6.7767523. [DOI] [PubMed] [Google Scholar]
  9. Leger P., Bedicam J. M., Cornette A., Reybet-Degat O., Langevin B., Polu J. M., Jeannin L., Robert D. Nasal intermittent positive pressure ventilation. Long-term follow-up in patients with severe chronic respiratory insufficiency. Chest. 1994 Jan;105(1):100–105. doi: 10.1378/chest.105.1.100. [DOI] [PubMed] [Google Scholar]
  10. Lightowler Josephine V., Wedzicha Jadwiga A., Elliott Mark W., Ram Felix S. F. Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis. BMJ. 2003 Jan 25;326(7382):185–185. doi: 10.1136/bmj.326.7382.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Perrin C., El Far Y., Vandenbos F., Tamisier R., Dumon M. C., Lemoigne F., Mouroux J., Blaive B. Domiciliary nasal intermittent positive pressure ventilation in severe COPD: effects on lung function and quality of life. Eur Respir J. 1997 Dec;10(12):2835–2839. doi: 10.1183/09031936.97.10122835. [DOI] [PubMed] [Google Scholar]
  12. Plant P. K., Owen J. L., Elliott M. W. Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial. Lancet. 2000 Jun 3;355(9219):1931–1935. doi: 10.1016/s0140-6736(00)02323-0. [DOI] [PubMed] [Google Scholar]
  13. Plant P. K., Owen J. L., Elliott M. W. Non-invasive ventilation in acute exacerbations of chronic obstructive pulmonary disease: long term survival and predictors of in-hospital outcome. Thorax. 2001 Sep;56(9):708–712. doi: 10.1136/thorax.56.9.708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Plant P. K., Owen J. L., Elliott M. W. One year period prevalence study of respiratory acidosis in acute exacerbations of COPD: implications for the provision of non-invasive ventilation and oxygen administration. Thorax. 2000 Jul;55(7):550–554. doi: 10.1136/thorax.55.7.550. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Plant P. K., Owen J. L., Parrott S., Elliott M. W. Cost effectiveness of ward based non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease: economic analysis of randomised controlled trial. BMJ. 2003 May 3;326(7396):956–956. doi: 10.1136/bmj.326.7396.956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Thys F., Roeseler J., Reynaert M., Liistro G., Rodenstein D. O. Noninvasive ventilation for acute respiratory failure: a prospective randomised placebo-controlled trial. Eur Respir J. 2002 Sep;20(3):545–555. doi: 10.1183/09031936.02.00287402. [DOI] [PubMed] [Google Scholar]

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