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. 1987 Jan;31(1):52–54. doi: 10.1128/aac.31.1.52

Vancomycin pharmacokinetics and dose recommendations for preterm infants.

A James, G Koren, J Milliken, S Soldin, C Prober
PMCID: PMC174650  PMID: 3566238

Abstract

The pharmacokinetics of intravenous vancomycin was studied in 20 preterm infants (gestational age, 26.5 weeks +/- 2.6 weeks [standard deviation]; birthweight, 880 +/- 340 g). At the time of the studies their postconceptional age was 36.4 +/- 4.5 weeks. The drug was infused over 30 min in a dose between 9.2 and 18 mg/kg. A highly significant correlation existed between postconceptional age or body weight and vancomycin t1/2 and clearance. Serum creatinine concentrations correlated with vancomycin t1/2 and clearance. Serum creatinine tended to decrease with increasing postconceptional age. Based on the excellent correlation between age (or weight) and vancomycin pharmacokinetics, dose and dose-interval recommendations are presented.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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