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. 1987 Jan;31(1):129–131. doi: 10.1128/aac.31.1.129

Suppression by Saccharomyces boulardii of toxigenic Clostridium difficile overgrowth after vancomycin treatment in hamsters.

G W Elmer, L V McFarland
PMCID: PMC174670  PMID: 3566236

Abstract

Saccharomyces boulardii prevented the development of high counts of Clostridium difficile, high titers of toxin B, and positive latex agglutination tests after cessation of vancomycin treatment for hamsters. The protocol used was designed to stimulate relapse of human C. difficile-associated colitis. S. boulardii was protective in this model.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banno Y., Kobayashi T., Kono H., Watanabe K., Ueno K., Nozawa Y. Biochemical characterization and biologic actions of two toxins (D-1 and D-2) from Clostridium difficile. Rev Infect Dis. 1984 Mar-Apr;6 (Suppl 1):S11–S20. doi: 10.1093/clinids/6.supplement_1.s11. [DOI] [PubMed] [Google Scholar]
  2. Bartlett J. G., Chang T. W., Onderdonk A. B. Comparison of five regimens for treatment of experimental clindamycin-associated colitis. J Infect Dis. 1978 Jul;138(1):81–86. doi: 10.1093/infdis/138.1.81. [DOI] [PubMed] [Google Scholar]
  3. Bartlett J. G., Tedesco F. J., Shull S., Lowe B., Chang T. Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis. Gastroenterology. 1980 Mar;78(3):431–434. [PubMed] [Google Scholar]
  4. Browne R. A., Fekety R., Jr, Silva J., Jr, Boyd D. I., Work C. O., Abrams G. D. The protective effect of vancomycin on clindamycin-induced colitis in hamsters. Johns Hopkins Med J. 1977 Oct;141(4):183–192. [PubMed] [Google Scholar]
  5. Ducluzeau R., Bensaada M. Effet comparé de l'administration unique ou en continu de Saccharomyces boulardii sur l'établissement de diverses souches de Candida dans le tractus digestif de souris gnotoxéniques. Ann Microbiol (Paris) 1982 Nov-Dec;133(3):491–501. [PubMed] [Google Scholar]
  6. George W. L., Rolfe R. D., Harding G. K., Klein R., Putnam C. W., Finegold S. M. Clostridium difficile and cytotoxin in feces of patients with antimicrobial agent-associated pseudomembranous colitis. Infection. 1982;10(4):205–208. doi: 10.1007/BF01666910. [DOI] [PubMed] [Google Scholar]
  7. George W. L., Volpicelli N. A., Stiner D. B., Richman D. D., Liechty E. J., Mok H. Y., Rolfe R. D., Finegold S. M. Relapse of pseudomembranous colitis after vancomycin therapy. N Engl J Med. 1979 Aug 23;301(8):414–415. doi: 10.1056/NEJM197908233010806. [DOI] [PubMed] [Google Scholar]
  8. Lyerly D. M., Wilkins T. D. Commercial latex test for Clostridium difficile toxin A does not detect toxin A. J Clin Microbiol. 1986 Mar;23(3):622–623. doi: 10.1128/jcm.23.3.622-623.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Massot J., Sanchez O., Couchy R., Astoin J., Parodi A. L. Bacterio-pharmacological activity of Saccharomyces boulardii in clindamycin-induced colitis in the hamster. Arzneimittelforschung. 1984;34(7):794–797. [PubMed] [Google Scholar]
  10. Peterson L. R., Holter J. J., Shanholtzer C. J., Garrett C. R., Gerding D. N. Detection of Clostridium difficile toxins A (enterotoxin) and B (cytotoxin) in clinical specimens. Evaluation of a latex agglutination test. Am J Clin Pathol. 1986 Aug;86(2):208–211. doi: 10.1093/ajcp/86.2.208. [DOI] [PubMed] [Google Scholar]
  11. Teasley D. G., Gerding D. N., Olson M. M., Peterson L. R., Gebhard R. L., Schwartz M. J., Lee J. T., Jr Prospective randomised trial of metronidazole versus vancomycin for Clostridium-difficile-associated diarrhoea and colitis. Lancet. 1983 Nov 5;2(8358):1043–1046. doi: 10.1016/s0140-6736(83)91036-x. [DOI] [PubMed] [Google Scholar]
  12. Tedesco F. J., Gordon D., Fortson W. C. Approach to patients with multiple relapses of antibiotic-associated pseudomembranous colitis. Am J Gastroenterol. 1985 Nov;80(11):867–868. [PubMed] [Google Scholar]
  13. Tempé J. D., Steidel A. L., Blehaut H., Hasselmann M., Lutun P., Maurier F. Prévention par saccharomyces boulardii des diarrhées de l'alimentation entérale à débit continu. Sem Hop. 1983 May 5;59(18):1409–1412. [PubMed] [Google Scholar]
  14. Toothaker R. D., Elmer G. W. Prevention of clindamycin-induced mortality in hamsters by Saccharomyces boulardii. Antimicrob Agents Chemother. 1984 Oct;26(4):552–556. doi: 10.1128/aac.26.4.552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ushijima H., Shinozaki T., Fujii R. Detection of Clostridium difficile enterotoxin in neonates by latex agglutination. Arch Dis Child. 1985 Mar;60(3):252–254. doi: 10.1136/adc.60.3.252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Walters B. A., Roberts R., Stafford R., Seneviratne E. Relapse of antibiotic associated colitis: endogenous persistence of Clostridium difficile during vancomycin therapy. Gut. 1983 Mar;24(3):206–212. doi: 10.1136/gut.24.3.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wilkinson I. J., Rich G., Moore B., Philpot C. R. Relapse of antibiotic-associated colitis after vancomycin therapy. Med J Aust. 1980 Apr 5;1(7):321–323. doi: 10.5694/j.1326-5377.1980.tb134883.x. [DOI] [PubMed] [Google Scholar]
  18. Willey S. H., Bartlett J. G. Cultures for Clostridium difficile in stools containing a cytotoxin neutralized by Clostridium sordellii antitoxin. J Clin Microbiol. 1979 Dec;10(6):880–884. doi: 10.1128/jcm.10.6.880-884.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Young G. P., Ward P. B., Bayley N., Gordon D., Higgins G., Trapani J. A., McDonald M. I., Labrooy J., Hecker R. Antibiotic-associated colitis due to Clostridium difficile: double-blind comparison of vancomycin with bacitracin. Gastroenterology. 1985 Nov;89(5):1038–1045. doi: 10.1016/0016-5085(85)90206-9. [DOI] [PubMed] [Google Scholar]
  20. van der Waaij D., Berghuis J. M., Lekkerkerk J. E. Colonization resistance of the digestive tract of mice during systemic antibiotic treatment. J Hyg (Lond) 1972 Dec;70(4):605–610. doi: 10.1017/s0022172400022464. [DOI] [PMC free article] [PubMed] [Google Scholar]

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