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. 2004 Mar;59(3):217–223. doi: 10.1136/thx.2003.008979

Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol

L Atzori 1, F Chua 1, S Dunsmore 1, D Willis 1, M Barbarisi 1, R McAnulty 1, G Laurent 1
PMCID: PMC1746982  PMID: 14985557

Abstract

Methods: Zndtp (10 µmol/kg) was administered subcutaneously twice daily to mice 1 week following the intratracheal instillation of 0.025 U bleomycin. Animals were killed 10 or 21 days after bleomycin instillation and indices of lung damage and fibrosis were evaluated.

Results: Bleomycin treatment induced pulmonary cytotoxicity, increased levels of active transforming growth factor ß (TGF-ß), enhanced lung collagen accumulation, and decreased glutathione content. Zndtp administration significantly attenuated these indices.

Conclusions: Administration of Zndtp in the bleomycin model resulted in appreciable alveolar cytoprotection and amelioration of pulmonary fibrosis. This molecule and its analogues may warrant further consideration in the treatment of acute lung injury and fibrotic lung disorders.

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Selected References

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