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. 2004 Sep;59(9):746–751. doi: 10.1136/thx.2003.013680

Association of domestic exposure to volatile organic compounds with asthma in young children

K Rumchev 1, J Spickett 1, M Bulsara 1, M Phillips 1, S Stick 1
PMCID: PMC1747137  PMID: 15333849

Abstract

Aim: To investigate the association between domestic exposure to volatile organic compounds (VOCs) and asthma in young children.

Methods: A population based case-control study was conducted in Perth, Western Australia in children aged between 6 months and 3 years. Cases (n = 88) were children recruited at Princess Margaret Hospital accident and emergency department and discharged with asthma as the primary diagnosis; 104 controls consisted of children from the same age group without an asthma diagnosis identified through the Health Department of Western Australia. Information regarding the health status of the study children and characteristics of the home was collected using a standardised questionnaire. Exposure to VOCs, average temperature and relative humidity were measured in winter and summer in the living room of each participating household.

Results: Cases were exposed to significantly higher VOC levels (µg/m3) than controls (p<0.01). Most of the individual VOCs appeared to be significant risk factors for asthma with the highest odds ratios for benzene followed by ethylbenzene and toluene. For every 10 unit increase in the concentration of toluene and benzene (µg/m3) the risk of having asthma increased by almost two and three times, respectively.

Conclusions: Domestic exposure to VOCs at levels below currently accepted recommendations may increase the risk of childhood asthma. Measurement of total VOCs may underestimate the risks associated with individual compounds.

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Selected References

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  1. Anderson H. R., Butland B. K., Strachan D. P. Trends in prevalence and severity of childhood asthma. BMJ. 1994 Jun 18;308(6944):1600–1604. doi: 10.1136/bmj.308.6944.1600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Burney P. G., Chinn S., Rona R. J. Has the prevalence of asthma increased in children? Evidence from the national study of health and growth 1973-86. BMJ. 1990 May 19;300(6735):1306–1310. doi: 10.1136/bmj.300.6735.1306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chaudhuri Rekha, McMahon Alex D., Thomson Lorna J., MacLeod Kirsten J., McSharry Charles P., Livingston Eric, McKay Anne, Thomson Neil C. Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. J Allergy Clin Immunol. 2004 Jun;113(6):1063–1070. doi: 10.1016/j.jaci.2004.03.019. [DOI] [PubMed] [Google Scholar]
  4. Environmental Controls and Lung Disease. Am Rev Respir Dis. 1990 Oct;142(4):915–939. doi: 10.1164/ajrccm/142.4.915. [DOI] [PubMed] [Google Scholar]
  5. Ferris B. G. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1–120. [PubMed] [Google Scholar]
  6. Gereda J. E., Klinnert M. D., Price M. R., Leung D. Y., Liu A. H. Metropolitan home living conditions associated with indoor endotoxin levels. J Allergy Clin Immunol. 2001 May;107(5):790–796. doi: 10.1067/mai.2001.115245. [DOI] [PubMed] [Google Scholar]
  7. Harving H., Dahl R., Mølhave L. Lung function and bronchial reactivity in asthmatics during exposure to volatile organic compounds. Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):751–754. doi: 10.1164/ajrccm/143.4_Pt_1.751. [DOI] [PubMed] [Google Scholar]
  8. Hyndman S. J., Brown D. L., Ewan P. W., Higenbottam T. W., Maunder J. W., Williams D. R. Humidity regulation in the management of asthma patients sensitized to house dust mites. Q J Med. 1994 Jun;87(6):367–372. [PubMed] [Google Scholar]
  9. Karol Meryl H. Respiratory allergy: what are the uncertainties? Toxicology. 2002 Dec 27;181-182:305–310. doi: 10.1016/s0300-483x(02)00298-6. [DOI] [PubMed] [Google Scholar]
  10. Koren H. S., Graham D. E., Devlin R. B. Exposure of humans to a volatile organic mixture. III. Inflammatory response. Arch Environ Health. 1992 Jan-Feb;47(1):39–44. doi: 10.1080/00039896.1992.9935942. [DOI] [PubMed] [Google Scholar]
  11. Luczynska C. M., Arruda L. K., Platts-Mills T. A., Miller J. D., Lopez M., Chapman M. D. A two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I. J Immunol Methods. 1989 Mar 31;118(2):227–235. doi: 10.1016/0022-1759(89)90010-0. [DOI] [PubMed] [Google Scholar]
  12. Meinert R., Frischer T., Karmaus W., Kuehr J. Influence of skin prick test criteria on estimation of prevalence and incidence of allergic sensitization in children. Allergy. 1994 Aug;49(7):526–532. doi: 10.1111/j.1398-9995.1994.tb01124.x. [DOI] [PubMed] [Google Scholar]
  13. Norbäck D., Björnsson E., Janson C., Widström J., Boman G. Asthmatic symptoms and volatile organic compounds, formaldehyde, and carbon dioxide in dwellings. Occup Environ Med. 1995 Jun;52(6):388–395. doi: 10.1136/oem.52.6.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Oddy W. H., de Klerk N. H., Sly P. D., Holt P. G. The effects of respiratory infections, atopy, and breastfeeding on childhood asthma. Eur Respir J. 2002 May;19(5):899–905. doi: 10.1183/09031936.02.00103602. [DOI] [PubMed] [Google Scholar]
  15. Peat J. K., van den Berg R. H., Green W. F., Mellis C. M., Leeder S. R., Woolcock A. J. Changing prevalence of asthma in Australian children. BMJ. 1994 Jun 18;308(6944):1591–1596. doi: 10.1136/bmj.308.6944.1591. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rumchev K. B., Spickett J. T., Bulsara M. K., Phillips M. R., Stick S. M. Domestic exposure to formaldehyde significantly increases the risk of asthma in young children. Eur Respir J. 2002 Aug;20(2):403–408. doi: 10.1183/09031936.02.00245002. [DOI] [PubMed] [Google Scholar]
  17. Wallace L. A. The exposure of the general population to benzene. Cell Biol Toxicol. 1989 Nov;5(3):297–314. doi: 10.1007/BF01795358. [DOI] [PubMed] [Google Scholar]
  18. Ware J. H., Spengler J. D., Neas L. M., Samet J. M., Wagner G. R., Coultas D., Ozkaynak H., Schwab M. Respiratory and irritant health effects of ambient volatile organic compounds. The Kanawha County Health Study. Am J Epidemiol. 1993 Jun 15;137(12):1287–1301. doi: 10.1093/oxfordjournals.aje.a116639. [DOI] [PubMed] [Google Scholar]
  19. Wieslander G., Norbäck D., Björnsson E., Janson C., Boman G. Asthma and the indoor environment: the significance of emission of formaldehyde and volatile organic compounds from newly painted indoor surfaces. Int Arch Occup Environ Health. 1997;69(2):115–124. doi: 10.1007/s004200050125. [DOI] [PubMed] [Google Scholar]
  20. Yuan Wei, Fonager Kirsten, Olsen Jørn, Sørensen Henrik Toft. Prenatal factors and use of anti-asthma medications in early childhood: a population-based Danish birth cohort study. Eur J Epidemiol. 2003;18(8):763–768. doi: 10.1023/a:1025390420122. [DOI] [PubMed] [Google Scholar]

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