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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1987 Feb;31(2):328–330. doi: 10.1128/aac.31.2.328

In vitro activity of A-56268 (TE-031), a new macrolide, compared with that of erythromycin and clindamycin against selected gram-positive and gram-negative organisms.

C A Benson, J Segreti, F E Beaudette, D W Hines, L J Goodman, R L Kaplan, G M Trenholme
PMCID: PMC174717  PMID: 2952063

Abstract

The in vitro activity of A-56268 was determined and compared with that of erythromycin and clindamycin against a limited spectrum of 401 gram-positive and gram-negative organisms. A-56268 was quite active against erythromycin-susceptible Staphylococcus aureus, Neisseria gonorrhoeae, Listeria monocytogenes, Streptococcus pneumoniae, Streptococcus pyogenes, and group B streptococci and was moderately active against Campylobacter fetus subsp. fetus. A-56268 was consistently bactericidal only for S. pneumoniae. The activity of A-56268 was comparable to that of erythromycin against most organisms tested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Edelstein P. H., Meyer R. D. Susceptibility of Legionella pneumophila to twenty antimicrobial agents. Antimicrob Agents Chemother. 1980 Sep;18(3):403–408. doi: 10.1128/aac.18.3.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Fliegelman R. M., Petrak R. M., Goodman L. J., Segreti J., Trenholme G. M., Kaplan R. L. Comparative in vitro activities of twelve antimicrobial agents against Campylobacter species. Antimicrob Agents Chemother. 1985 Mar;27(3):429–430. doi: 10.1128/aac.27.3.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Jao R. L. Susceptibility of Mycoplasma pneumoniae to 21 antibiotics in vitro. Am J Med Sci. 1967 Jun;253(6):639–650. doi: 10.1097/00000441-196706000-00001. [DOI] [PubMed] [Google Scholar]
  4. Kuo C. C., Wang S. P., Grayston J. T. Antimicrobial activity of several antibiotics and a sulfonamide against Chlamydia trachomatis organisms in cell culture. Antimicrob Agents Chemother. 1977 Jul;12(1):80–83. doi: 10.1128/aac.12.1.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Nicholas P. Erythromycin: clinical review I. Clinical pharmacology. N Y State J Med. 1977 Nov;77(13):2088–2094. [PubMed] [Google Scholar]
  6. Nicholas P. Erythromycin: clinical review. II. Therapeutic uses. N Y State J Med. 1977 Dec;77(14):2243–2246. [PubMed] [Google Scholar]

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