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. 1987 Feb;31(2):335–336. doi: 10.1128/aac.31.2.335

Effect of Candida morphology on amphotericin B susceptibility.

K M Nugent, K R Couchot, L D Gray
PMCID: PMC174720  PMID: 3551836

Abstract

We showed that brief exposures to amphotericin B (AmB) inhibited the induction of new Candida germ tubes and the lengthening of partially induced germ tubes. Blastoconidia with germ tubes were more susceptible to AmB killing, and this varied directly with the induction period and the AmB exposure period. AmB did not preferentially affect germ tube adherence to fibrin matrices.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borgers M., De Brabander M., Van Den Bossche H., Van Cutsem J. Promotion of pseudomycelium formation of Candida albicans in culture: a morphological study of the effects of miconazole and ketoconazole. Postgrad Med J. 1979 Sep;55(647):687–691. doi: 10.1136/pgmj.55.647.687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brajtburg J., Elberg S., Schwartz D. R., Vertut-Croquin A., Schlessinger D., Kobayashi G. S., Medoff G. Involvement of oxidative damage in erythrocyte lysis induced by amphotericin B. Antimicrob Agents Chemother. 1985 Feb;27(2):172–176. doi: 10.1128/aac.27.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brajtburg J., Medoff G., Kobayashi G. S., Elberg S. Influence of extracellular K+ or Mg2+ on the stages of the antifungal effects of amphotericin B and filipin. Antimicrob Agents Chemother. 1980 Oct;18(4):593–597. doi: 10.1128/aac.18.4.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Klotz S. A., Drutz D. J., Zajic J. E. Factors governing adherence of Candida species to plastic surfaces. Infect Immun. 1985 Oct;50(1):97–101. doi: 10.1128/iai.50.1.97-101.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Maisch P. A., Calderone R. A. Adherence of Candida albicans to a fibrin-platelet matrix formed in vitro. Infect Immun. 1980 Feb;27(2):650–656. doi: 10.1128/iai.27.2.650-656.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Niimi M., Kamiyama A., Tokunaga M., Tokunaga J., Nakayama H. Germ tube-forming cells of Candida albicans are more susceptible to clotrimazole-induced killing than yeast cells. Sabouraudia. 1985 Feb;23(1):63–68. [PubMed] [Google Scholar]
  7. Nugent K. M., Couchot K. R. Effects of sublethal concentrations of amphotericin B on Candida albicans. J Infect Dis. 1986 Oct;154(4):665–669. doi: 10.1093/infdis/154.4.665. [DOI] [PubMed] [Google Scholar]
  8. Rast D. M., Bartnicki-Garcia S. Effects of amphotericin B, nystatin, and other polyene antibiotics on chitin synthase. Proc Natl Acad Sci U S A. 1981 Feb;78(2):1233–1236. doi: 10.1073/pnas.78.2.1233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Soll D. R., Bedell G. W., Brummel M. Zinc and regulation of growth and phenotype in the infectious yeast Candida albicans. Infect Immun. 1981 Jun;32(3):1139–1147. doi: 10.1128/iai.32.3.1139-1147.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Staebell M., Soll D. R. Temporal and spatial differences in cell wall expansion during bud and mycelium formation in Candida albicans. J Gen Microbiol. 1985 Jun;131(6):1467–1480. doi: 10.1099/00221287-131-6-1467. [DOI] [PubMed] [Google Scholar]
  11. Wood N. C., Nugent K. M. Inhibitory effects of chlorpromazine on Candida species. Antimicrob Agents Chemother. 1985 May;27(5):692–694. doi: 10.1128/aac.27.5.692. [DOI] [PMC free article] [PubMed] [Google Scholar]

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