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. 2005 Oct 21;60(11):967–970. doi: 10.1136/thx.2004.033852

Exhaled nitric oxide in sarcoidosis

M Wilsher 1, W Fergusson 1, D Milne 1, A Wells 1
PMCID: PMC1747239  PMID: 16244094

Abstract

Background: Increased production of nitric oxide (NO) by the lower respiratory tract is viewed as a marker of airway inflammation in asthma and bronchiectasis. NO is a potentially important immune modulator, inhibiting the release of several key pro-inflammatory cytokines. As sarcoidosis is characterised by granulomatous airway inflammation, we hypothesised that exhaled NO levels might be raised in sarcoidosis and correlate with the morphological extent and functional severity of disease.

Methods: Fifty two patients with sarcoidosis (29 men) of mean age 42 years underwent thin section computed tomography (CT), pulmonary function tests, and measurement of exhaled NO.

Results: Exhaled NO levels (median 6.8 ppb, range 2.4–21.8) did not differ significantly from values in 44 control subjects, and were not related to the extent of individual CT abnormalities or the level of pulmonary function impairment.

Conclusion: Exhaled NO levels are not increased in pulmonary sarcoidosis.

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Selected References

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  1. Greene C. M., Meachery G., Taggart C. C., Rooney C. P., Coakley R., O'Neill S. J., McElvaney N. G. Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis. J Immunol. 2000 Oct 15;165(8):4718–4724. doi: 10.4049/jimmunol.165.8.4718. [DOI] [PubMed] [Google Scholar]
  2. Hansell D. M., Milne D. G., Wilsher M. L., Wells A. U. Pulmonary sarcoidosis: morphologic associations of airflow obstruction at thin-section CT. Radiology. 1998 Dec;209(3):697–704. doi: 10.1148/radiology.209.3.9844661. [DOI] [PubMed] [Google Scholar]
  3. Hoffman Lucas R., D'Argenio David A., MacCoss Michael J., Zhang Zhaoying, Jones Roger A., Miller Samuel I. Aminoglycoside antibiotics induce bacterial biofilm formation. Nature. 2005 Aug 25;436(7054):1171–1175. doi: 10.1038/nature03912. [DOI] [PubMed] [Google Scholar]
  4. Kharitonov S. A., Yates D. H., Barnes P. J. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med. 1996 Jan;153(1):454–457. doi: 10.1164/ajrccm.153.1.8542158. [DOI] [PubMed] [Google Scholar]
  5. Kharitonov S. A., Yates D., Robbins R. A., Logan-Sinclair R., Shinebourne E. A., Barnes P. J. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994 Jan 15;343(8890):133–135. doi: 10.1016/s0140-6736(94)90931-8. [DOI] [PubMed] [Google Scholar]
  6. Lakari Essi, Soini Ylermi, Säily Marjaana, Koistinen Pirjo, Päkkö Paavo, Kinnula Vuokko L. Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung. Am J Clin Pathol. 2002 Jan;117(1):132–142. doi: 10.1309/w7t9-hw9v-v94b-r9km. [DOI] [PubMed] [Google Scholar]
  7. Moller D. R. Cells and cytokines involved in the pathogenesis of sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 1999 Mar;16(1):24–31. [PubMed] [Google Scholar]
  8. Moodley Y. P., Chetty R., Lalloo U. G. Nitric oxide levels in exhaled air and inducible nitric oxide synthase immunolocalization in pulmonary sarcoidosis. Eur Respir J. 1999 Oct;14(4):822–827. doi: 10.1034/j.1399-3003.1999.14d17.x. [DOI] [PubMed] [Google Scholar]
  9. Moodley Y. P., Lalloo U. G. Exhaled nitric oxide is elevated in patients with progressive systemic sclerosis without interstitial lung disease. Chest. 2001 May;119(5):1449–1454. doi: 10.1378/chest.119.5.1449. [DOI] [PubMed] [Google Scholar]
  10. Moody A., Fergusson W., Wells A., Bartley J., Kolbe J. Increased nitric oxide production in the respiratory tract in asymptomatic pacific islanders: an association with skin prick reactivity to house dust mite. J Allergy Clin Immunol. 2000 May;105(5):895–899. doi: 10.1067/mai.2000.105318. [DOI] [PubMed] [Google Scholar]
  11. O'Donnell D. M., Moynihan J., Finlay G. A., Keatings V. M., O'Connor C. M., McLoughlin P., Fitzgerald M. X. Exhaled nitric oxide and bronchoalveolar lavage nitrite/nitrate in active pulmonary sarcoidosis. Am J Respir Crit Care Med. 1997 Dec;156(6):1892–1896. doi: 10.1164/ajrccm.156.6.9705013. [DOI] [PubMed] [Google Scholar]
  12. Paredi P., Kharitonov S. A., Loukides S., Pantelidis P., du Bois R. M., Barnes P. J. Exhaled nitric oxide is increased in active fibrosing alveolitis. Chest. 1999 May;115(5):1352–1356. doi: 10.1378/chest.115.5.1352. [DOI] [PubMed] [Google Scholar]
  13. Ricciardolo F. L. M. Multiple roles of nitric oxide in the airways. Thorax. 2003 Feb;58(2):175–182. doi: 10.1136/thorax.58.2.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Roberts H. R., Wells A. U., Milne D. G., Rubens M. B., Kolbe J., Cole P. J., Hansell D. M. Airflow obstruction in bronchiectasis: correlation between computed tomography features and pulmonary function tests. Thorax. 2000 Mar;55(3):198–204. doi: 10.1136/thorax.55.3.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Saleh D., Ernst P., Lim S., Barnes P. J., Giaid A. Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid. FASEB J. 1998 Aug;12(11):929–937. [PubMed] [Google Scholar]
  16. Standardized lung function testing. Report working party. Bull Eur Physiopathol Respir. 1983 Jul;19 (Suppl 5):1–95. [PubMed] [Google Scholar]
  17. Taylor-Robinson A. W., Liew F. Y., Severn A., Xu D., McSorley S. J., Garside P., Padron J., Phillips R. S. Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur J Immunol. 1994 Apr;24(4):980–984. doi: 10.1002/eji.1830240430. [DOI] [PubMed] [Google Scholar]

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