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. 2005 Jun;60(6):521–523. doi: 10.1136/thx.2005.040139

Fundoplication eliminates chronic cough due to non-acid reflux identified by impedance pH monitoring

I Mainie 1, R Tutuian 1, A Agrawal 1, A Hila 1, K Highland 1, D Adams 1, D Castell 1
PMCID: PMC1747420  PMID: 15923255

Abstract

The symptoms of extra-oesophageal gastro-oesophageal reflux disease (GORD) (such as chronic cough and hoarseness) are traditionally more difficult to treat than typical GORD symptoms (heartburn and regurgitation). Patients with extra-oesophageal manifestations may require longer and higher doses of acid suppressive therapy. In patients not responding to acid suppressive therapy the physician faces a dilemma as to whether the symptoms are due to ongoing acid reflux, non-acid reflux, or not associated with reflux. We report the case of a 45 year old woman with a history of a chronic cough referred for fundoplication after documenting her symptoms were associated with non-acid reflux using multichannel intraluminal impedance and pH (MII-pH).

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