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. 2005 Jun;60(6):462–466. doi: 10.1136/thx.2004.027532

Association between short term exposure to fine particulate matter and heart rate variability in older subjects with and without heart disease

J Sullivan 1, A Schreuder 1, C Trenga 1, S Liu 1, T Larson 1, J Koenig 1, J Kaufman 1
PMCID: PMC1747435  PMID: 15923245

Abstract

Background: Short term increases in exposure to particulate matter (PM) air pollution are associated with increased cardiovascular morbidity and mortality. The mechanism behind this effect is unclear, although changes in autonomic control have been observed. It was hypothesised that increases in fine PM measured at the subjects' home in the preceding hour would be associated with decreased high frequency heart rate variability (HF-HRV) in individuals with pre-existing cardiac disease.

Methods: Two hundred and eighty five daily 20 minute measures of HRV (including a paced breathing protocol) were made in the homes of 34 elderly individuals with (n = 21) and without (n = 13) cardiovascular disease (CVD) over a 10 day period in Seattle between February 2000 and March 2002. Fine PM was continuously measured by nephelometry at the individuals' homes.

Results: The median age of the study population was 77 years (range 57–87) and 44% were male. Models that adjusted for health status, relative humidity, temperature, mean heart rate, and medication use did not find a significant association between a 10 µg/m3 increase in 1 hour mean outdoor PM2.5 before the HRV measurement and a change in HF-HRV power in individuals with CVD (3% increase in median HF-HRV (95% CI –19 to 32)) or without CVD (5% decrease in median HF-HRV (95% CI –34 to 36)). Similarly, no association was evident using 4 hour and 24 hour mean outdoor PM2.5 exposures before the HRV measurement.

Conclusion: No association was found between increased residence levels of fine PM and frequency domain measures of HRV in elderly individuals.

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Selected References

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  1. Bigger J. T., Jr, Rolnitzky L. M., Steinman R. C., Fleiss J. L. Predicting mortality after myocardial infarction from the response of RR variability to antiarrhythmic drug therapy. J Am Coll Cardiol. 1994 Mar 1;23(3):733–740. doi: 10.1016/0735-1097(94)90761-7. [DOI] [PubMed] [Google Scholar]
  2. Bilchick Kenneth C., Fetics Barry, Djoukeng Ronnie, Fisher Susan Gross, Fletcher Ross D., Singh Steven N., Nevo Erez, Berger Ronald D. Prognostic value of heart rate variability in chronic congestive heart failure (Veterans Affairs' Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure). Am J Cardiol. 2002 Jul 1;90(1):24–28. doi: 10.1016/s0002-9149(02)02380-9. [DOI] [PubMed] [Google Scholar]
  3. Campen M. J., Nolan J. P., Schladweiler M. C., Kodavanti U. P., Evansky P. A., Costa D. L., Watkinson W. P. Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: a potential interaction between nickel and vanadium sulfate. Toxicol Sci. 2001 Dec;64(2):243–252. doi: 10.1093/toxsci/64.2.243. [DOI] [PubMed] [Google Scholar]
  4. Cheng Tsun-Jen, Hwang Jing-Shiang, Wang Peng-Yau, Tsai Chia-Fang, Chen Chun-Yen, Lin Sheng-Hsiang, Chan Chang-Chuan. Effects of concentrated ambient particles on heart rate and blood pressure in pulmonary hypertensive rats. Environ Health Perspect. 2003 Feb;111(2):147–150. doi: 10.1289/ehp.5464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dockery D. W., Pope C. A., 3rd, Xu X., Spengler J. D., Ware J. H., Fay M. E., Ferris B. G., Jr, Speizer F. E. An association between air pollution and mortality in six U.S. cities. N Engl J Med. 1993 Dec 9;329(24):1753–1759. doi: 10.1056/NEJM199312093292401. [DOI] [PubMed] [Google Scholar]
  6. Godleski J. J., Verrier R. L., Koutrakis P., Catalano P., Coull B., Reinisch U., Lovett E. G., Lawrence J., Murthy G. G., Wolfson J. M. Mechanisms of morbidity and mortality from exposure to ambient air particles. Res Rep Health Eff Inst. 2000 Feb;(91):5–103. [PubMed] [Google Scholar]
  7. Gold D. R., Litonjua A., Schwartz J., Lovett E., Larson A., Nearing B., Allen G., Verrier M., Cherry R., Verrier R. Ambient pollution and heart rate variability. Circulation. 2000 Mar 21;101(11):1267–1273. doi: 10.1161/01.cir.101.11.1267. [DOI] [PubMed] [Google Scholar]
  8. Goldberg M. S., Burnett R. T., Bailar J. C., 3rd, Brook J., Bonvalot Y., Tamblyn R., Singh R., Valois M. F., Vincent R. The association between daily mortality and ambient air particle pollution in Montreal, Quebec. 2. Cause-specific mortality. Environ Res. 2001 May;86(1):26–36. doi: 10.1006/enrs.2001.4243. [DOI] [PubMed] [Google Scholar]
  9. Hohnloser S. H., Klingenheben T., Zabel M., Li Y. G. Heart rate variability used as an arrhythmia risk stratifier after myocardial infarction. Pacing Clin Electrophysiol. 1997 Oct;20(10 Pt 2):2594–2601. doi: 10.1111/j.1540-8159.1997.tb06109.x. [DOI] [PubMed] [Google Scholar]
  10. Holguín Fernando, Téllez-Rojo Marta M., Hernández Mauricio, Cortez Marlene, Chow Judith C., Watson John G., Mannino David, Romieu Isabelle. Air pollution and heart rate variability among the elderly in Mexico City. Epidemiology. 2003 Sep;14(5):521–527. doi: 10.1097/01.ede.0000081999.15060.ae. [DOI] [PubMed] [Google Scholar]
  11. La Rovere Maria Teresa, Pinna Gian Domenico, Maestri Roberto, Mortara Andrea, Capomolla Soccorso, Febo Oreste, Ferrari Roberto, Franchini Mariella, Gnemmi Marco, Opasich Cristina. Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation. 2003 Feb 4;107(4):565–570. doi: 10.1161/01.cir.0000047275.25795.17. [DOI] [PubMed] [Google Scholar]
  12. Lampert Rachel, Ickovics Jeannette R., Viscoli Catherine J., Horwitz Ralph I., Lee Forrester A. Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial. Am J Cardiol. 2003 Jan 15;91(2):137–142. doi: 10.1016/s0002-9149(02)03098-9. [DOI] [PubMed] [Google Scholar]
  13. Le Tertre A., Medina S., Samoli E., Forsberg B., Michelozzi P., Boumghar A., Vonk J. M., Bellini A., Atkinson R., Ayres J. G. Short-term effects of particulate air pollution on cardiovascular diseases in eight European cities. J Epidemiol Community Health. 2002 Oct;56(10):773–779. doi: 10.1136/jech.56.10.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Levy D., Sheppard L., Checkoway H., Kaufman J., Lumley T., Koenig J., Siscovick D. A case-crossover analysis of particulate matter air pollution and out-of-hospital primary cardiac arrest. Epidemiology. 2001 Mar;12(2):193–199. [PubMed] [Google Scholar]
  15. Liao D., Creason J., Shy C., Williams R., Watts R., Zweidinger R. Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. Environ Health Perspect. 1999 Jul;107(7):521–525. doi: 10.1289/ehp.99107521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Liao Duanping, Duan Yinkang, Whitsel Eric A., Zheng Zhi-jie, Heiss Gerardo, Chinchilli Vernon M., Lin Hung-Mo. Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: a population-based study. Am J Epidemiol. 2004 Apr 15;159(8):768–777. doi: 10.1093/aje/kwh109. [DOI] [PubMed] [Google Scholar]
  17. Liu L. J. Sally, Slaughter James C., Larson Timothy V. Comparison of light scattering devices and impactors for particulate measurements in indoor, outdoor, and personal environments. Environ Sci Technol. 2002 Jul 1;36(13):2977–2986. doi: 10.1021/es0112644. [DOI] [PubMed] [Google Scholar]
  18. Lombardi F., Porta A., Marzegalli M., Favale S., Santini M., Vincenti A., De Rosa A., Implantable Cardioverter Defibrillator-Heart Rate Variability Italian Study Group Heart rate variability patterns before ventricular tachycardia onset in patients with an implantable cardioverter defibrillator. Participating Investigators of ICD-HRV Italian Study Group. Am J Cardiol. 2000 Nov 1;86(9):959–963. doi: 10.1016/s0002-9149(00)01130-9. [DOI] [PubMed] [Google Scholar]
  19. Magari Shannon R., Schwartz Joel, Williams Paige L., Hauser Russ, Smith Thomas J., Christiani David C. The association of particulate air metal concentrations with heart rate variability. Environ Health Perspect. 2002 Sep;110(9):875–880. doi: 10.1289/ehp.02110875. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Mehta MC, Jain AC, Mehta A, Billie M. Cardiac Arrhythmias Following Intravenous Nicotine: Experimental Study in Dogs. J Cardiovasc Pharmacol Ther. 1997 Oct;2(4):291–298. doi: 10.1177/107424849700200407. [DOI] [PubMed] [Google Scholar]
  21. Molinelli Alejandro R., Madden Michael C., McGee John K., Stonehuerner Jacqueline G., Ghio Andrew J. Effect of metal removal on the toxicity of airborne particulate matter from the Utah Valley. Inhal Toxicol. 2002 Oct;14(10):1069–1086. doi: 10.1080/08958370290084737. [DOI] [PubMed] [Google Scholar]
  22. Peters A., Dockery D. W., Muller J. E., Mittleman M. A. Increased particulate air pollution and the triggering of myocardial infarction. Circulation. 2001 Jun 12;103(23):2810–2815. doi: 10.1161/01.cir.103.23.2810. [DOI] [PubMed] [Google Scholar]
  23. Peters A., Liu E., Verrier R. L., Schwartz J., Gold D. R., Mittleman M., Baliff J., Oh J. A., Allen G., Monahan K. Air pollution and incidence of cardiac arrhythmia. Epidemiology. 2000 Jan;11(1):11–17. doi: 10.1097/00001648-200001000-00005. [DOI] [PubMed] [Google Scholar]
  24. Pope C. A., 3rd, Verrier R. L., Lovett E. G., Larson A. C., Raizenne M. E., Kanner R. E., Schwartz J., Villegas G. M., Gold D. R., Dockery D. W. Heart rate variability associated with particulate air pollution. Am Heart J. 1999 Nov;138(5 Pt 1):890–899. doi: 10.1016/s0002-8703(99)70014-1. [DOI] [PubMed] [Google Scholar]
  25. Pope C. Arden, 3rd, Hansen Matthew L., Long Russell W., Nielsen Karen R., Eatough Norman L., Wilson William E., Eatough Delbert J. Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. Environ Health Perspect. 2004 Mar;112(3):339–345. doi: 10.1289/ehp.6588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Priori S. G., Aliot E., Blomstrom-Lundqvist C., Bossaert L., Breithardt G., Brugada P., Camm A. J., Cappato R., Cobbe S. M., Di Mario C. Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J. 2001 Aug;22(16):1374–1450. doi: 10.1053/euhj.2001.2824. [DOI] [PubMed] [Google Scholar]
  27. Pruvot E., Thonet G., Vesin J. M., van-Melle G., Seidl K., Schmidinger H., Brachmann J., Jung W., Hoffmann E., Tavernier R. Heart rate dynamics at the onset of ventricular tachyarrhythmias as retrieved from implantable cardioverter-defibrillators in patients with coronary artery disease. Circulation. 2000 May 23;101(20):2398–2404. doi: 10.1161/01.cir.101.20.2398. [DOI] [PubMed] [Google Scholar]
  28. Samet J. M., Dominici F., Curriero F. C., Coursac I., Zeger S. L. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med. 2000 Dec 14;343(24):1742–1749. doi: 10.1056/NEJM200012143432401. [DOI] [PubMed] [Google Scholar]
  29. Samet J. M., Zeger S. L., Dominici F., Curriero F., Coursac I., Dockery D. W., Schwartz J., Zanobetti A. The National Morbidity, Mortality, and Air Pollution Study. Part II: Morbidity and mortality from air pollution in the United States. Res Rep Health Eff Inst. 2000 Jun;94(Pt 2):5–79. [PubMed] [Google Scholar]
  30. Sarnat Jeremy A., Long Christopher M., Koutrakis Petros, Coull Brent A., Schwartz Joel, Suh Helen H. Using sulfur as a tracer of outdoor fine particulate matter. Environ Sci Technol. 2002 Dec 15;36(24):5305–5314. doi: 10.1021/es025796b. [DOI] [PubMed] [Google Scholar]
  31. Schwartz J., Morris R. Air pollution and hospital admissions for cardiovascular disease in Detroit, Michigan. Am J Epidemiol. 1995 Jul 1;142(1):23–35. doi: 10.1093/oxfordjournals.aje.a117541. [DOI] [PubMed] [Google Scholar]
  32. Spooner P. M., Albert C., Benjamin E. J., Boineau R., Elston R. C., George A. L., Jr, Jouven X., Kuller L. H., MacCluer J. W., Marbán E. Sudden cardiac death, genes, and arrhythmogenesis : consideration of new population and mechanistic approaches from a national heart, lung, and blood institute workshop, part I. Circulation. 2001 May 15;103(19):2361–2364. doi: 10.1161/01.cir.103.19.2361. [DOI] [PubMed] [Google Scholar]
  33. Sullivan J., Ishikawa N., Sheppard L., Siscovick D., Checkoway H., Kaufman J. Exposure to ambient fine particulate matter and primary cardiac arrest among persons with and without clinically recognized heart disease. Am J Epidemiol. 2003 Mar 15;157(6):501–509. doi: 10.1093/aje/kwg015. [DOI] [PubMed] [Google Scholar]
  34. Wellenius Gregory A., Saldiva Paulo H. N., Batalha Joao R. F., Krishna Murthy G. G., Coull Brent A., Verrier Richard L., Godleski John J. Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarction. Toxicol Sci. 2002 Apr;66(2):327–335. doi: 10.1093/toxsci/66.2.327. [DOI] [PubMed] [Google Scholar]
  35. Whitsel E. A., Raghunathan T. E., Pearce R. M., Lin D., Rautaharju P. M., Lemaitre R., Siscovick D. S. RR interval variation, the QT interval index and risk of primary cardiac arrest among patients without clinically recognized heart disease. Eur Heart J. 2001 Jan;22(2):165–173. doi: 10.1053/euhj.2000.2262. [DOI] [PubMed] [Google Scholar]

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