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. 1987 Mar;31(3):470–472. doi: 10.1128/aac.31.3.470

In vitro activity of Ro 15-8074, Ro 19-5247, A-56268, and roxithromycin (RU 28965) against Neisseria gonorrhoeae and Chlamydia trachomatis.

W R Bowie, C E Shaw, D G Chan, W A Black
PMCID: PMC174756  PMID: 2953304

Abstract

In vitro Ro 15-8074 and Ro 19-5247 (T2525), two new oral cephalosporins, were active against 410 penicillin-susceptible and -resistant isolates of Neisseria gonorrhoeae. Two new macrolides, A-56268 and to a lesser extent roxithromycin (RU 28965), were active against Chlamydia trachomatis. A-56268 had activity against N. gonorrhoeae similar to that of erythromycin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bowie W. R., Lee C. K., Alexander E. R. Prediction of efficacy of antimicrobial agents in treatment of infections due to Chlamydia trachomatis. J Infect Dis. 1978 Nov;138(5):655–659. doi: 10.1093/infdis/138.5.655. [DOI] [PubMed] [Google Scholar]
  2. Bowie W. R., Manzon L. M., Borrie-Hume C. J., Fawcett A., Jones H. D. Efficacy of treatment regimens for lower urogenital Chlamydia trachomatis infection in women. Am J Obstet Gynecol. 1982 Jan 15;142(2):125–129. doi: 10.1016/s0002-9378(16)32325-0. [DOI] [PubMed] [Google Scholar]
  3. Bowie W. R., Shaw C. E., Chan D. G., Jones H. D., Black W. A. In-vitro susceptibility of 400 isolates of Neisseria gonorrhoeae in Vancouver, 1982-84. CMAJ. 1986 Sep 1;135(5):489–493. [PMC free article] [PubMed] [Google Scholar]
  4. Jones R. N., Barry A. L., Thornsberry C. In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs. Antimicrob Agents Chemother. 1983 Aug;24(2):209–215. doi: 10.1128/aac.24.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jorgensen J. H., Lee J. C., Alexander G. A. Rapid penicillinase paper strip test for detection of beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1977 Jun;11(6):1087–1088. doi: 10.1128/aac.11.6.1087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Mourad A., Sweet R. L., Sugg N., Schachter J. Relative resistance to erythromycin in Chlamydia trachomatis. Antimicrob Agents Chemother. 1980 Nov;18(5):696–698. doi: 10.1128/aac.18.5.696. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ng W. S., Chau P. Y., Leung Y. K., Wong P. C. In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1985 Sep;28(3):461–463. doi: 10.1128/aac.28.3.461. [DOI] [PMC free article] [PubMed] [Google Scholar]

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