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. 1987 Apr;31(4):614–616. doi: 10.1128/aac.31.4.614

Monocyclic and tricyclic analogs of quinolones: mechanism of action.

N H Georgopapadakou, B A Dix, P Angehrn, A Wick, G L Olson
PMCID: PMC174788  PMID: 3037999

Abstract

The mode of action of Ro 13-5478 and Ro 14-9578, monocyclic and tricyclic quinolone analogs, respectively, was examined for Escherichia coli and Staphylococcus aureus. The compounds showed antibacterial activity and effects on cell morphology, replicative DNA biosynthesis, and gyrase-catalyzed DNA supercoiling that were comparable to those shown by nalidixic acid and by oxolinic acid compounds. The results suggest that their site of action is DNA gyrase and that a bicyclic quinolone nucleus is not essential for activity.

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Selected References

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