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. 1987 Apr;31(4):622–624. doi: 10.1128/aac.31.4.622

In vitro activity of zinc salts against human rhinoviruses.

F C Geist, J A Bateman, F G Hayden
PMCID: PMC174791  PMID: 3038000

Abstract

The antiviral activity of zinc salts against rhinovirus types 1A and 39 was assayed by yield reduction and inhibition of cytopathic effect in cell culture. The findings indicate that the zinc salts tested have low in vitro therapeutic indices and suggest that the possible beneficial effects of zinc lozenges in reducing cold symptoms may not be related to selective antirhinovirus activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Eby G. A., Davis D. R., Halcomb W. W. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother. 1984 Jan;25(1):20–24. doi: 10.1128/aac.25.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Greenberg S. B., Harris D., Giles P., Martin R. R., Wallace R. J., Jr Inhibition of Chlamydia trachomatis growth in McCoy, HeLa, and human prostate cells by zinc. Antimicrob Agents Chemother. 1985 Jun;27(6):953–957. doi: 10.1128/aac.27.6.953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Katz E., Margalith E. Inhibition of vaccinia virus maturation by zinc chloride. Antimicrob Agents Chemother. 1981 Feb;19(2):213–217. doi: 10.1128/aac.19.2.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Korant B. D., Butterworth B. E. Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides. J Virol. 1976 Apr;18(1):298–306. doi: 10.1128/jvi.18.1.298-306.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Korant B. D., Kauer J. C., Butterworth B. E. Zinc ions inhibit replication of rhinoviruses. Nature. 1974 Apr 12;248(449):588–590. doi: 10.1038/248588a0. [DOI] [PubMed] [Google Scholar]
  6. Shlomai J., Asher Y., Gordon Y. J., Olshevsky U., Becker Y. Effect of zinc ions on the synthesis of herpes simplex virus DNA in infected BSC-1 cells. Virology. 1975 Jul;66(1):330–335. doi: 10.1016/0042-6822(75)90204-4. [DOI] [PubMed] [Google Scholar]
  7. Sugarman B. Zinc and infection. Rev Infect Dis. 1983 Jan-Feb;5(1):137–147. doi: 10.1093/clinids/5.1.137. [DOI] [PubMed] [Google Scholar]

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