Abstract
We studied the effect of the control of the hypothyroid state in humans on the pharmacokinetic parameters of cefazolin and gentamicin after a single intravenous injection. These two antibiotics were chosen because of their different patterns of binding to serum albumin (0% for gentamicin and 82% for cefazolin). In hypothyroidism, the behavior of cefazolin only was altered, with a decrease in the total body clearance, possibly due to reduced urinary excretion, and a decrease in the volume of distribution without a significant alteration of cefazolin binding to serum protein.
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- BREWER D. B. Myxoedema: an autopsy report with histochemical observations on the nature of the mucoid infiltrations. J Pathol Bacteriol. 1951 Jul;63(3):503–512. doi: 10.1002/path.1700630318. [DOI] [PubMed] [Google Scholar]
- Benveniste R., Davies J. Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor. Biochemistry. 1971 May 11;10(10):1787–1796. doi: 10.1021/bi00786a009. [DOI] [PubMed] [Google Scholar]
- Brisson A. M., Fourtillan J. B. Determination of cephalosporins in biological material by reversed-phase liquid column chromatography. J Chromatogr. 1981 May 8;223(2):393–399. doi: 10.1016/s0378-4347(00)80112-7. [DOI] [PubMed] [Google Scholar]
- Carbon C., Contrepois A., Brion N., Lamotte-Barrillon S. Penetration of cefazolin, cephaloridine, and cefamandole into interstitial fluid in rabbits. Antimicrob Agents Chemother. 1977 Apr;11(4):594–598. doi: 10.1128/aac.11.4.594. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carbon C., Contrepois A., Nivoche Y., Grandjean M., Decourt S., Chau N. P. Effects of phenylbutazone on extravascular diffusion, protein binding and urinary excretion of cefazolin in rabbits. J Pharmacol Exp Ther. 1981 Aug;218(2):537–543. [PubMed] [Google Scholar]
- Contrepois A., Brion N., Garaud J. J., Faurisson F., Delatour F., Levy J. C., Deybach J. C., Carbon C. Renal disposition of gentamicin, dibekacin, tobramycin, netilmicin, and amikacin in humans. Antimicrob Agents Chemother. 1985 Apr;27(4):520–524. doi: 10.1128/aac.27.4.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Craig W. A., Vogelman B. Changing patterns of hospital infections: implications for therapy. Changing concepts and new applications of antibiotic pharmacokinetics. Am J Med. 1984 Jul 31;77(1B):24–28. doi: 10.1016/s0002-9343(84)80092-3. [DOI] [PubMed] [Google Scholar]
- Feely J., Stevenson I. H., Crooks J. Altered plasma protein binding of drugs in thyroid disease. Clin Pharmacokinet. 1981 Jul-Aug;6(4):298–305. doi: 10.2165/00003088-198106040-00004. [DOI] [PubMed] [Google Scholar]
- Morgant C., Contrepois A., Chau N. P., Romaru A., Fourtillan J. B., Carbon C. Effects of furosemide, piretanide, and water loading on urinary excretion of cefazolin in humans. Antimicrob Agents Chemother. 1984 May;25(5):618–621. doi: 10.1128/aac.25.5.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parving H. H., Hansen J. M., Nielsen S. L., Rossing N., Munck O., Lassen N. A. Mechanisms of edema formation in myxedema--increased protein extravasation and relatively slow lymphatic drainage. N Engl J Med. 1979 Aug 30;301(9):460–465. doi: 10.1056/NEJM197908303010902. [DOI] [PubMed] [Google Scholar]
- Sachdev Y., Hall R. Effusions into body cavities in hypothyroidism. Lancet. 1975 Mar 8;1(7906):564–566. doi: 10.1016/s0140-6736(75)91571-8. [DOI] [PubMed] [Google Scholar]
- Wagner J. G. Pharmacokinetic data. Pharmacokinetic parameters estimated from intravenous data by uniform methods and some of their uses. J Pharmacokinet Biopharm. 1977 Apr;5(2):161–182. doi: 10.1007/BF01066219. [DOI] [PubMed] [Google Scholar]