Abstract
The activity of BMY-28100, a new orally administered cephalosporin, was compared with those of cephalexin and cefaclor. BMY-28100 was the most active drug against Staphylococcus aureus (MIC for 90% of strains tested [MIC90], 1.0 microgram/ml), streptococci (MIC90S, less than or equal to 0.125 microgram/ml), and Klebsiella pneumoniae (MIC90, 2 micrograms/ml). The drug was active against Haemophilus influenzae and gonococci but not against other organisms generally resistant to cephem antibiotics.
Full text
PDF![653](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3685/174801/cd36732c366a/aac00095-0201.png)
![654](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3685/174801/bdf1dd6e6ec9/aac00095-0202.png)
![655](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3685/174801/d498f45e3f13/aac00095-0203.png)
![656](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3685/174801/e9fd680742c7/aac00095-0204.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Eliopoulos G. M., Gardella A., Moellering R. C., Jr In-vitro activity of Sch 29482 in comparison with other oral antibiotics. J Antimicrob Chemother. 1982 Feb;9 (Suppl 100):143–152. doi: 10.1093/jac/9.suppl_c.143. [DOI] [PubMed] [Google Scholar]
- Glew R. H., Moellering R. C., Jr Effect of protein binding on the activity of penicillins in combination with gentamicin against enterococci. Antimicrob Agents Chemother. 1979 Jan;15(1):87–92. doi: 10.1128/aac.15.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murray B. E., Karchmer A. W., Moellering R. C., Jr Diphtheroid prosthetic valve endocarditis. A study of clinical features and infecting organisms. Am J Med. 1980 Dec;69(6):838–848. doi: 10.1016/s0002-9343(80)80009-x. [DOI] [PubMed] [Google Scholar]