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. 1987 May;31(5):813–814. doi: 10.1128/aac.31.5.813

Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery.

U Frank, I Kappstein, E Schmidt-Eisenlohr, V Schlosser, G Spillner, M Schindler, F D Daschner
PMCID: PMC174840  PMID: 3300542

Abstract

Patients undergoing open-heart surgery were given an intravenous bolus injection of 2 g of ceftazidime as a single dose over a period of 5 min. Within 12 h, ceftazidime concentrations in serum declined from 55.8 to 3.9 mg/liter. Subcutaneous tissue concentrations of the drug decreased from 21.0 to 2.7 micrograms/g, and muscle concentrations decreased from 34.5 to 2.5 micrograms/g. Ceftazidime concentrations in cardiac valvular tissue were even higher than those in muscle or fat, declining from 37.4 to 6.3 micrograms/g within 10 h.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balant L., Dayer P., Auckenthaler R. Clinical pharmacokinetics of the third generation cephalosporins. Clin Pharmacokinet. 1985 Mar-Apr;10(2):101–143. doi: 10.2165/00003088-198510020-00001. [DOI] [PubMed] [Google Scholar]
  2. Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Harding S. M., Harper P. B. The pharmacokinetic behaviour of ceftazidime in man and the relationship between serum levels and the in vitro susceptibility of clinical isolates. Infection. 1983;11 (Suppl 1):S49–S53. doi: 10.1007/BF01641107. [DOI] [PubMed] [Google Scholar]
  4. McColm A. A., Ryan D. M. Comparative pharmacokinetics of ceftazidime in fibrin clots and cardiac vegetations in rabbits with Staphylococcus aureus endocarditis. Antimicrob Agents Chemother. 1985 Jun;27(6):925–927. doi: 10.1128/aac.27.6.925. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Richards D. M., Brogden R. N. Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985 Feb;29(2):105–161. doi: 10.2165/00003495-198529020-00002. [DOI] [PubMed] [Google Scholar]
  6. Sharpe A. N., Jackson A. K. Stomaching: a new concept in bacteriological sample preparation. Appl Microbiol. 1972 Aug;24(2):175–178. doi: 10.1128/am.24.2.175-178.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]

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