Abstract
LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold higher, i.e., 5 mg/day.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bartlett J. G., Onderdonk A. B., Cisneros R. L., Kasper D. L. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters. J Infect Dis. 1977 Nov;136(5):701–705. doi: 10.1093/infdis/136.5.701. [DOI] [PubMed] [Google Scholar]
- Browne R. A., Fekety R., Jr, Silva J., Jr, Boyd D. I., Work C. O., Abrams G. D. The protective effect of vancomycin on clindamycin-induced colitis in hamsters. Johns Hopkins Med J. 1977 Oct;141(4):183–192. [PubMed] [Google Scholar]
- Chang T. W., Gorbach S. L., Bartlett J. B. Neutralization of Clostridium difficile toxin by Clostridium sordellii antitoxins. Infect Immun. 1978 Nov;22(2):418–422. doi: 10.1128/iai.22.2.418-422.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Faruki H., Niles A. C., Heeren R. L., Murray P. R. Effect of calcium on in vitro activity of LY146032 against Clostridium difficile. Antimicrob Agents Chemother. 1987 Mar;31(3):461–462. doi: 10.1128/aac.31.3.461. [DOI] [PMC free article] [PubMed] [Google Scholar]