Abstract
Single doses of rimantadine were given to children and young adults to evaluate the safety and pharmacokinetics of this antiviral compound. The half-life of rimantadine in young adults was 27.7 +/- 4.9 h for tablets and 27.8 +/- 8.0 h for syrup preparations. A total of 10 children, 5 to 8 years old, received a syrup preparation of rimantadine. The half-life of rimantadine in children was 24.8 +/- 9.4 h. A single dose of rimantadine was well tolerated in young adults and children.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Glezen W. P., Paredes A., Taber L. H. Influenza in children. Relationship to other respiratory agents. JAMA. 1980 Apr 4;243(13):1345–1349. doi: 10.1001/jama.243.13.1345. [DOI] [PubMed] [Google Scholar]
- Hayden F. G., Gwaltney J. M., Jr, Van de Castle R. L., Adams K. F., Giordani B. Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults. Antimicrob Agents Chemother. 1981 Feb;19(2):226–233. doi: 10.1128/aac.19.2.226. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hayden F. G., Hoffman H. E., Spyker D. A. Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics. Antimicrob Agents Chemother. 1983 Mar;23(3):458–464. doi: 10.1128/aac.23.3.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hayden F. G., Minocha A., Spyker D. A., Hoffman H. E. Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults. Antimicrob Agents Chemother. 1985 Aug;28(2):216–221. doi: 10.1128/aac.28.2.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mullooly J. P., Barker W. H. Impact of type A influenza on children: a retrospective study. Am J Public Health. 1982 Sep;72(9):1008–1016. doi: 10.2105/ajph.72.9.1008. [DOI] [PMC free article] [PubMed] [Google Scholar]