Abstract
The passage of antifungal agents into pulmonary parenchyma was studied in normal sheep prepared by cannulation of the right external jugular vein and the efferent duct of the right caudal mediastinal lymph node. Five sheep were given single, sequential, intravenous injections of flucytosine, ketoconazole, BAY n 7133, amphotericin B methyl ester, and amphotericin B. Venous blood plasma and pulmonary lymph were collected before infusion and from 5 min to 24 h postinfusion; the concentrations of the drugs were assayed by a well-agar diffusion method. All drugs appeared promptly in the pulmonary lymph and disappeared at approximately exponential rates from both liquids. The lymph/plasma ratios of the drug concentrations did not differ between flucytosine and the two azoles but were lower for both polyenes. Binding by plasma proteins did not appear to be a determinant of pulmonary entry.
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Selected References
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- Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brajtburg J., Elberg S., Bolard J., Kobayashi G. S., Levy R. A., Ostlund R. E., Jr, Schlessinger D., Medoff G. Interaction of plasma proteins and lipoproteins with amphotericin B. J Infect Dis. 1984 Jun;149(6):986–997. doi: 10.1093/infdis/149.6.986. [DOI] [PubMed] [Google Scholar]
- Cohen S. H., Hoeprich P. D., Demling R., Gunther R., Merry J. M., Franti C. E., Miner D. J. Entry of four cephalosporins into the ovine lung. J Infect Dis. 1984 Feb;149(2):264–270. doi: 10.1093/infdis/149.2.264. [DOI] [PubMed] [Google Scholar]
- Hoeprich P. D., Huston A. C. Susceptibility of coccidioides immitis, Candida albicans, and Cryptococcus neoformans to amphotericin B, flucytosine, and clotrimazole. J Infect Dis. 1975 Aug;132(2):133–141. doi: 10.1093/infdis/132.2.133. [DOI] [PubMed] [Google Scholar]
- Hoeprich P. D., Merry J. M. In vitro activities of two new antifungal azoles. Antimicrob Agents Chemother. 1984 Mar;25(3):339–341. doi: 10.1128/aac.25.3.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoeprich P. D., Merry J. M. Influence of culture medium on susceptibility testing with BAY n 7133 and ketoconazole. J Clin Microbiol. 1986 Aug;24(2):269–271. doi: 10.1128/jcm.24.2.269-271.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huston A. C., Hoeprich P. D. Comparative susceptibility of four kinds of pathogenic fungi to amphotericin B and amphotericin B methyl ester. Antimicrob Agents Chemother. 1978 Jun;13(6):905–909. doi: 10.1128/aac.13.6.905. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lunde P. K., Rane A., Yaffe S. J., Lund L., Sjöqvist F. Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution. Clin Pharmacol Ther. 1970 Nov-Dec;11(6):846–855. doi: 10.1002/cpt1970116846. [DOI] [PubMed] [Google Scholar]
- Wayland H., Silberberg A. Blood to lymph transport. Microvasc Res. 1978 May;15(3):367–374. doi: 10.1016/0026-2862(78)90038-9. [DOI] [PubMed] [Google Scholar]