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. 1987 Aug;31(8):1274–1277. doi: 10.1128/aac.31.8.1274

Detection of a second mechanism of resistance to gentamicin in animal strains of Escherichia coli.

E Chaslus-Dancla, G Gerbaud, J L Martel, M Lagorce, J P Lafont, P Courvalin
PMCID: PMC174918  PMID: 3307622

Abstract

One mechanism of plasmid-mediated resistance to gentamicin in Escherichia coli strains isolated from animals is due to the synthesis of the aminoglycoside 3-N-acetyltransferase type IV. A second mechanism of plasmid-mediated resistance to gentamicin was detected in animal strains of E. coli in France and is due to the production of the aminoglycoside 3-N-acetyltransferase type II. The molecular relationships among plasmids encoding this enzyme were studied.

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Selected References

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  1. Acar J. F., Goldstein F. W., Menard R., Bleriot J. P. Strategies in aminoglycoside use and impact upon resistance. Am J Med. 1986 Jun 30;80(6B):82–87. [PubMed] [Google Scholar]
  2. Chabbert Y. A., Scavizzi M. R., Witchitz J. L., Gerbaud G. R., Bouanchaud D. H. Incompatibility groups and the classification of fi - resistance factors. J Bacteriol. 1972 Nov;112(2):666–675. doi: 10.1128/jb.112.2.666-675.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chaslus-Dancla E., Lafont J. P. Resistance to gentamicin and apramycin in Escherichia coli from calves in France. Vet Rec. 1985 Jul 27;117(4):90–91. doi: 10.1136/vr.117.4.90. [DOI] [PubMed] [Google Scholar]
  4. Chaslus-Dancla E., Martel J. L., Carlier C., Lafont J. P., Courvalin P. Emergence of aminoglycoside 3-N-acetyltransferase IV in Escherichia coli and Salmonella typhimurium isolated from animals in France. Antimicrob Agents Chemother. 1986 Feb;29(2):239–243. doi: 10.1128/aac.29.2.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Courvalin P., Carlier C. Resistance towards aminoglycoside-aminocyclitol antibiotics in bacteria. J Antimicrob Chemother. 1981 Jul;8 (Suppl A):57–69. doi: 10.1093/jac/8.suppl_a.57. [DOI] [PubMed] [Google Scholar]
  6. Davies J., Smith D. I. Plasmid-determined resistance to antimicrobial agents. Annu Rev Microbiol. 1978;32:469–518. doi: 10.1146/annurev.mi.32.100178.002345. [DOI] [PubMed] [Google Scholar]
  7. Foster T. J. Plasmid-determined resistance to antimicrobial drugs and toxic metal ions in bacteria. Microbiol Rev. 1983 Sep;47(3):361–409. doi: 10.1128/mr.47.3.361-409.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Haas M. J., Dowding J. E. Aminoglycoside-modifying enzymes. Methods Enzymol. 1975;43:611–628. doi: 10.1016/0076-6879(75)43124-x. [DOI] [PubMed] [Google Scholar]
  9. Le Goffic F., Martel A., Witchitz J. 3-N enzymatic acetylation of gentamicin, tobramycin, and kanamycin by Escherichia coli carrying an R factor. Antimicrob Agents Chemother. 1974 Dec;6(6):680–684. doi: 10.1128/aac.6.6.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Macrina F. L., Kopecko D. J., Jones K. R., Ayers D. J., McCowen S. M. A multiple plasmid-containing Escherichia coli strain: convenient source of size reference plasmid molecules. Plasmid. 1978 Jun;1(3):417–420. doi: 10.1016/0147-619x(78)90056-2. [DOI] [PubMed] [Google Scholar]
  11. Maes P. Evaluation of the resistance mechanisms of gentamicin-resistant Gram-negative bacilli and their susceptibility to tobramycin, netilmicin and amikacin. J Antimicrob Chemother. 1985 Mar;15(3):283–289. doi: 10.1093/jac/15.3.283. [DOI] [PubMed] [Google Scholar]
  12. Novick R. P., Clowes R. C., Cohen S. N., Curtiss R., 3rd, Datta N., Falkow S. Uniform nomenclature for bacterial plasmids: a proposal. Bacteriol Rev. 1976 Mar;40(1):168–189. doi: 10.1128/br.40.1.168-189.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Phillips I., Shannon K. Aminoglycoside resistance. Br Med Bull. 1984 Jan;40(1):28–35. doi: 10.1093/oxfordjournals.bmb.a071943. [DOI] [PubMed] [Google Scholar]
  14. Takahashi S., Nagano Y. Rapid procedure for isolation of plasmid DNA and application to epidemiological analysis. J Clin Microbiol. 1984 Oct;20(4):608–613. doi: 10.1128/jcm.20.4.608-613.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WATANABE T., FUKASAWA T. Episome-mediated transfer of drug resistance in Enterobacteriaceae. I. Transfer of resistance factors by conjugation. J Bacteriol. 1961 May;81:669–678. doi: 10.1128/jb.81.5.669-678.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Witchitz J. L. Epidemiological aspects of aminoglycoside resistance in France. J Antimicrob Chemother. 1981 Jul;8 (Suppl A):71–82. doi: 10.1093/jac/8.suppl_a.71. [DOI] [PubMed] [Google Scholar]

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