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. 1987 Sep;31(9):1423–1425. doi: 10.1128/aac.31.9.1423

Increased susceptibility to cephamycin-type antibiotics of methicillin-resistant Staphylococcus aureus defective in penicillin-binding protein 2.

K Murakami 1, K Nomura 1, M Doi 1, T Yoshida 1
PMCID: PMC174954  PMID: 3499862

Abstract

A methicillin-resistant strain of Staphylococcus aureus which produced low-affinity penicillin-binding protein 2' (PBP 2') spontaneously lost PBP 2 when the strain was cultivated at 43 degrees C overnight. At 37 degrees C, the mutant had increased susceptibility to cephamycin-type beta-lactams, which showed high affinity for PBP 4. This result suggests that inhibition of PBP 4, in addition to that of PBP 2, is necessary to kill methicillin-resistant strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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