Abstract
Women with recurrent urinary tract infections treated with cefuroxime axetil (500 or 250 mg twice daily) for 7 days had a higher relapse rate when tested 6 weeks after the start of treatment than those given amoxycillin (250 mg three times daily). The poor performance of cefuroxime axetil is explained by variable bioavailability.
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Selected References
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- Adams D. H., Wood M. J., Farrell I. D., Fox C., Ball A. P. Oral cefuroxime axetil: clinical pharmacology and comparative dose studies in urinary tract infection. J Antimicrob Chemother. 1985 Sep;16(3):359–366. doi: 10.1093/jac/16.3.359. [DOI] [PubMed] [Google Scholar]
- Brumfitt W., Hamilton-Miller J. M. Changing role of co-trimoxazole in the treatment of recurrent urinary infections: a comparison with augmentin. Br J Clin Pract. 1985 Sep;39(9):346–351. [PubMed] [Google Scholar]
- Brumfitt W., Hamilton-Miller J. M., Ludlam H., Damjanovic V., Gargan R. Comparative trial of trimethoprim and co-trimoxazole in recurrent urinary infections. Infection. 1982 Sep-Oct;10(5):280–284. doi: 10.1007/BF01640874. [DOI] [PubMed] [Google Scholar]
- Brumfitt W., Smith G. W., Hamilton-Miller J. M., Bax R. Successful use of reduced dosage of cinoxacin in the treatment of recurrent urinary infection. J Antimicrob Chemother. 1985 Dec;16(6):781–788. doi: 10.1093/jac/16.6.781. [DOI] [PubMed] [Google Scholar]
- Cooper T. J., Ladusans E., Williams P. E., Polychronopoulos V., Gaya H., Rudd R. M. A comparison of oral cefuroxime axetil and oral amoxycillin in lower respiratory tract infections. J Antimicrob Chemother. 1985 Sep;16(3):373–378. doi: 10.1093/jac/16.3.373. [DOI] [PubMed] [Google Scholar]
- Gargan R., Brumfitt W., Hamilton-Miller J. M. A concise biotyping system for differentiating strains of Escherichia coli. J Clin Pathol. 1982 Dec;35(12):1366–1369. doi: 10.1136/jcp.35.12.1366. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harding S. M., Williams P. E., Ayrton J. Pharmacology of Cefuroxime as the 1-acetoxyethyl ester in volunteers. Antimicrob Agents Chemother. 1984 Jan;25(1):78–82. doi: 10.1128/aac.25.1.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Callaghan C. H., Sykes R. B., Ryan D. M., Foord R. D., Muggleton P. W. Cefuroxime - a new cephalosporin antibiotic. J Antibiot (Tokyo) 1976 Jan;29(1):29–37. doi: 10.7164/antibiotics.29.29. [DOI] [PubMed] [Google Scholar]
- Reichman R. C., Nolte F. S., Wolinsky S. M., Greisberger C. A., Trupei M. A., Nitzkin J. Single-dose cefuroxime axetil in the treatment of uncomplicated gonorrhea: a controlled trial. Sex Transm Dis. 1985 Oct-Dec;12(4):184–187. doi: 10.1097/00007435-198510000-00003. [DOI] [PubMed] [Google Scholar]
- Sommers D. K., Van Wyk M., Williams P. E., Harding S. M. Pharmacokinetics and tolerance of cefuroxime axetil in volunteers during repeated dosing. Antimicrob Agents Chemother. 1984 Mar;25(3):344–347. doi: 10.1128/aac.25.3.344. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams P. E., Harding S. M. The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food. J Antimicrob Chemother. 1984 Feb;13(2):191–196. doi: 10.1093/jac/13.2.191. [DOI] [PubMed] [Google Scholar]
- Wise R., Bennett S. A., Dent J. The pharmacokinetics of orally absorbed cefuroxime compared with amoxycillin/clavulanic acid. J Antimicrob Chemother. 1984 Jun;13(6):603–610. doi: 10.1093/jac/13.6.603. [DOI] [PubMed] [Google Scholar]