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. 1987 Oct;31(10):1642–1643. doi: 10.1128/aac.31.10.1642

Plasmid-mediated sulfonamide resistance in Neisseria meningitidis.

B Facinelli 1, P E Varaldo 1
PMCID: PMC175006  PMID: 3124735

Abstract

An 8.5-megadalton plasmid coding for sulfonamide resistance was found in a clinical isolate of Neisseria meningitidis, as demonstrated by plasmid elimination and transformation experiments. The plasmid complemented a mutation which determines the production of a thermosensitive dihydropteroate synthetase in Escherichia coli, thus suggesting that the mechanism of resistance involved a plasmid-encoded dihydropteroate synthetase.

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Selected References

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