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. 1987 Nov;31(11):1689–1691. doi: 10.1128/aac.31.11.1689

Vancomycin entry into lung lymph in sheep.

D G May 1, C W Stratton 1, W D Denney 1, F L Watts 1, G R Bernard 1, R A Branch 1
PMCID: PMC175021  PMID: 3435116

Abstract

The distribution of antibiotics into target tissues is a crucial factor in therapeutic efficacy. To estimate the availability of systemically administered vancomycin to the interstitial fluid in the lung, we have used a sheep model with a chronic pulmonary lymph fistula to collect simultaneously series of plasma and pulmonary lymph specimens during a 6-h period after an intravenous dose of vancomycin (7 mg/kg). After a minor delay in transit from blood to lymph, vancomycin was completely distributed to pulmonary lymph with a ratio of free drug in lymph to free drug in plasma of 0.9. This suggests that vancomycin is an excellent choice for treating pulmonary infections by susceptible organisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bergogne-Berezin E., Morel C., Benard Y., Berthelot G., Kafe H. Pharmacokinetic study of beta-lactam antibiotics in bronchial secretions. Scand J Infect Dis Suppl. 1978;(14):267–272. [PubMed] [Google Scholar]
  2. Bergogne-Berezin E. Penetration of antibiotics into the respiratory tree. J Antimicrob Chemother. 1981 Sep;8(3):171–174. doi: 10.1093/jac/8.3.171. [DOI] [PubMed] [Google Scholar]
  3. Berk S. L., Verghese A., Holtsclaw S. A., Smith J. K. Enterococcal pneumonia. Occurrence in patients receiving broad-spectrum antibiotic regimens and enteral feeding. Am J Med. 1983 Jan;74(1):153–154. doi: 10.1016/0002-9343(83)91132-4. [DOI] [PubMed] [Google Scholar]
  4. Christensen G. D., Bisno A. L., Parisi J. T., McLaughlin B., Hester M. G., Luther R. W. Nosocomial septicemia due to multiply antibiotic-resistant Staphylococcus epidermidis. Ann Intern Med. 1982 Jan;96(1):1–10. doi: 10.7326/0003-4819-96-1-1. [DOI] [PubMed] [Google Scholar]
  5. Cohen S. H., Hoeprich P. D., Demling R., Gunther R., Merry J. M., Franti C. E., Miner D. J. Entry of four cephalosporins into the ovine lung. J Infect Dis. 1984 Feb;149(2):264–270. doi: 10.1093/infdis/149.2.264. [DOI] [PubMed] [Google Scholar]
  6. Krogstad D. J., Moellering R. C., Jr, Greenblatt D. J. Single-dose kinetics of intravenous vancomycin. J Clin Pharmacol. 1980 Apr;20(4 Pt 1):197–201. doi: 10.1002/j.1552-4604.1980.tb01696.x. [DOI] [PubMed] [Google Scholar]
  7. Kuperman A. S., Fernandez R. B. Subacute staphylococcal pneumonia. Am Rev Respir Dis. 1970 Jan;101(1):95–100. doi: 10.1164/arrd.1970.101.1.95. [DOI] [PubMed] [Google Scholar]
  8. Lambert H. P. Clinical significance of tissue penetration of antibiotics in the respiratory tract. Scand J Infect Dis Suppl. 1978;(14):262–266. [PubMed] [Google Scholar]
  9. Moellering R. C., Jr, Krogstad D. J., Greenblatt D. J. Pharmacokinetics of vancomycin in normal subjects and in patients with reduced renal function. Rev Infect Dis. 1981 Nov-Dec;3 Suppl:S230–S235. [PubMed] [Google Scholar]
  10. Rotschafer J. C., Crossley K., Zaske D. E., Mead K., Sawchuk R. J., Solem L. D. Pharmacokinetics of vancomycin: observations in 28 patients and dosage recommendations. Antimicrob Agents Chemother. 1982 Sep;22(3):391–394. doi: 10.1128/aac.22.3.391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Schwenzer K. S., Wang C. H., Anhalt J. P. Automated fluorescence polarization immunoassay for monitoring vancomycin. Ther Drug Monit. 1983;5(3):341–345. doi: 10.1097/00007691-198309000-00017. [DOI] [PubMed] [Google Scholar]
  12. Sorrell T. C., Packham D. R., Shanker S., Foldes M., Munro R. Vancomycin therapy for methicillin-resistant Staphylococcus aureus. Ann Intern Med. 1982 Sep;97(3):344–350. doi: 10.7326/0003-4819-97-3-344. [DOI] [PubMed] [Google Scholar]
  13. Staub N. C., Bland R. D., Brigham K. L., Demling R., Erdmann A. J., 3rd, Woolverton W. C. Preparation of chronic lung lymph fistulas in sheep. J Surg Res. 1975 Nov;19(5):315–320. doi: 10.1016/0022-4804(75)90056-6. [DOI] [PubMed] [Google Scholar]
  14. Szabo G., Magyar Z. s., Pósch E. The relationship between tissue fluid and lymph. Lymphology. 1976 Dec;9(4):145–149. [PubMed] [Google Scholar]
  15. Wong G. A., Pierce T. H., Goldstein E., Hoeprich P. D. Penetration of antimicrobial agents into bronchial secretions. Am J Med. 1975 Aug;59(2):219–223. doi: 10.1016/0002-9343(75)90356-3. [DOI] [PubMed] [Google Scholar]

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