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. 1987 Nov;31(11):1689–1691. doi: 10.1128/aac.31.11.1689

Vancomycin entry into lung lymph in sheep.

D G May 1, C W Stratton 1, W D Denney 1, F L Watts 1, G R Bernard 1, R A Branch 1
PMCID: PMC175021  PMID: 3435116

Abstract

The distribution of antibiotics into target tissues is a crucial factor in therapeutic efficacy. To estimate the availability of systemically administered vancomycin to the interstitial fluid in the lung, we have used a sheep model with a chronic pulmonary lymph fistula to collect simultaneously series of plasma and pulmonary lymph specimens during a 6-h period after an intravenous dose of vancomycin (7 mg/kg). After a minor delay in transit from blood to lymph, vancomycin was completely distributed to pulmonary lymph with a ratio of free drug in lymph to free drug in plasma of 0.9. This suggests that vancomycin is an excellent choice for treating pulmonary infections by susceptible organisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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