Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1987 Nov;31(11):1843–1845. doi: 10.1128/aac.31.11.1843

Effects of rokitamycin and other macrolide antibiotics on Mycoplasma pneumoniae in L cells.

T Misu 1, S Arai 1, M Furukawa 1, Y Yamamoto 1, T Miyazaki 1
PMCID: PMC175050  PMID: 3124740

Abstract

Fifty strains of Mycoplasma pneumoniae in L cells were tested for susceptibility to macrolide antibiotics. Rokitamycin, a new macrolide antibiotic, was most active against these organisms, with an MIC for 90% of strains of 0.007 microgram/ml. The MICs of erythromycin, josamycin, and kitasamycin for 90% of strains were 0.03, 0.03, and greater than or equal to 0.06 microgram/ml, respectively. Based on these results, rokitamycin is a promising antibiotic for the treatment of mycoplasmal infections, and further clinical investigations are needed.

Full text

PDF
1843

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arai S., Yuri Y., Kudo A., Kikuchi M., Kumagai K. Effect of antibiotics on the growth of various strains of Mycoplasma. J Antibiot (Tokyo) 1967 Sep;20(5):246–253. [PubMed] [Google Scholar]
  2. Baseman J. B., Cole R. M., Krause D. C., Leith D. K. Molecular basis for cytadsorption of Mycoplasma pneumoniae. J Bacteriol. 1982 Sep;151(3):1514–1522. doi: 10.1128/jb.151.3.1514-1522.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CHANOCK R. M., HAYFLICK L., BARILE M. F. Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO. Proc Natl Acad Sci U S A. 1962 Jan 15;48:41–49. doi: 10.1073/pnas.48.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CLYDE W. A., Jr Demonstration of Eaton's agent in tissue culture. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:715–718. doi: 10.3181/00379727-107-26732. [DOI] [PubMed] [Google Scholar]
  5. Collier A. M., Clyde W. A. Relationships Between Mycoplasma pneumoniae and Human Respiratory Epithelium. Infect Immun. 1971 May;3(5):694–701. doi: 10.1128/iai.3.5.694-701.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hu P. C., Cole R. M., Huang Y. S., Graham J. A., Gardner D. E., Collier A. M., Clyde W. A., Jr Mycoplasma pneumoniae infection: role of a surface protein in the attachment organelle. Science. 1982 Apr 16;216(4543):313–315. doi: 10.1126/science.6801766. [DOI] [PubMed] [Google Scholar]
  7. Hu P. C., Collier A. M., Baseman J. B. Alterations in the metabolism of hamster tracheas in organ culture after infection by virulent Mycoplasma pneumoniae. Infect Immun. 1975 Apr;11(4):704–710. doi: 10.1128/iai.11.4.704-710.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Marcus M., Lavi U., Nattenberg A., Rottem S., Markowitz O. Selective killing of mycoplasmas from contaminated mammalian cells in cell cultures. Nature. 1980 Jun 26;285(5767):659–661. doi: 10.1038/285659a0. [DOI] [PubMed] [Google Scholar]
  9. Powell D. A., Hu P. C., Wilson M., Collier A. M., Baseman J. B. Attachment of Mycoplasma pneumoniae to respiratory epithelium. Infect Immun. 1976 Mar;13(3):959–966. doi: 10.1128/iai.13.3.959-966.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sakakibara H., Okekawa O., Fujiwara T., Aizawa M., Omura S. Acyl derivatives of 16-membered macrolides. II. Antibacterial activities and serum levels of 3"-O-acyl derivatives of leucomycin. J Antibiot (Tokyo) 1981 Aug;34(8):1011–1018. doi: 10.7164/antibiotics.34.1011. [DOI] [PubMed] [Google Scholar]
  11. Sakakibara H., Okekawa O., Fujiwara T., Otani M., Omura S. Acyl derivatives of 16-membered macrolides. I. Synthesis and biological properties of 3"-O-propionylleucomycin A5 (TMS-19-Q). J Antibiot (Tokyo) 1981 Aug;34(8):1001–1010. doi: 10.7164/antibiotics.34.1001. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES