Abstract
Fifty strains of Mycoplasma pneumoniae in L cells were tested for susceptibility to macrolide antibiotics. Rokitamycin, a new macrolide antibiotic, was most active against these organisms, with an MIC for 90% of strains of 0.007 microgram/ml. The MICs of erythromycin, josamycin, and kitasamycin for 90% of strains were 0.03, 0.03, and greater than or equal to 0.06 microgram/ml, respectively. Based on these results, rokitamycin is a promising antibiotic for the treatment of mycoplasmal infections, and further clinical investigations are needed.
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- Arai S., Yuri Y., Kudo A., Kikuchi M., Kumagai K. Effect of antibiotics on the growth of various strains of Mycoplasma. J Antibiot (Tokyo) 1967 Sep;20(5):246–253. [PubMed] [Google Scholar]
- Baseman J. B., Cole R. M., Krause D. C., Leith D. K. Molecular basis for cytadsorption of Mycoplasma pneumoniae. J Bacteriol. 1982 Sep;151(3):1514–1522. doi: 10.1128/jb.151.3.1514-1522.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHANOCK R. M., HAYFLICK L., BARILE M. F. Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO. Proc Natl Acad Sci U S A. 1962 Jan 15;48:41–49. doi: 10.1073/pnas.48.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CLYDE W. A., Jr Demonstration of Eaton's agent in tissue culture. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:715–718. doi: 10.3181/00379727-107-26732. [DOI] [PubMed] [Google Scholar]
- Collier A. M., Clyde W. A. Relationships Between Mycoplasma pneumoniae and Human Respiratory Epithelium. Infect Immun. 1971 May;3(5):694–701. doi: 10.1128/iai.3.5.694-701.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hu P. C., Cole R. M., Huang Y. S., Graham J. A., Gardner D. E., Collier A. M., Clyde W. A., Jr Mycoplasma pneumoniae infection: role of a surface protein in the attachment organelle. Science. 1982 Apr 16;216(4543):313–315. doi: 10.1126/science.6801766. [DOI] [PubMed] [Google Scholar]
- Hu P. C., Collier A. M., Baseman J. B. Alterations in the metabolism of hamster tracheas in organ culture after infection by virulent Mycoplasma pneumoniae. Infect Immun. 1975 Apr;11(4):704–710. doi: 10.1128/iai.11.4.704-710.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marcus M., Lavi U., Nattenberg A., Rottem S., Markowitz O. Selective killing of mycoplasmas from contaminated mammalian cells in cell cultures. Nature. 1980 Jun 26;285(5767):659–661. doi: 10.1038/285659a0. [DOI] [PubMed] [Google Scholar]
- Powell D. A., Hu P. C., Wilson M., Collier A. M., Baseman J. B. Attachment of Mycoplasma pneumoniae to respiratory epithelium. Infect Immun. 1976 Mar;13(3):959–966. doi: 10.1128/iai.13.3.959-966.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sakakibara H., Okekawa O., Fujiwara T., Aizawa M., Omura S. Acyl derivatives of 16-membered macrolides. II. Antibacterial activities and serum levels of 3"-O-acyl derivatives of leucomycin. J Antibiot (Tokyo) 1981 Aug;34(8):1011–1018. doi: 10.7164/antibiotics.34.1011. [DOI] [PubMed] [Google Scholar]
- Sakakibara H., Okekawa O., Fujiwara T., Otani M., Omura S. Acyl derivatives of 16-membered macrolides. I. Synthesis and biological properties of 3"-O-propionylleucomycin A5 (TMS-19-Q). J Antibiot (Tokyo) 1981 Aug;34(8):1001–1010. doi: 10.7164/antibiotics.34.1001. [DOI] [PubMed] [Google Scholar]