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. 1997 Mar;65(3):1098–1100. doi: 10.1128/iai.65.3.1098-1100.1997

Humoral immune responses of Solomon Islanders to the merozoite surface antigen 2 of Plasmodium falciparum show pronounced skewing towards antibodies of the immunoglobulin G3 subclass.

C M Rzepczyk 1, K Hale 1, N Woodroffe 1, A Bobogare 1, P Csurhes 1, A Ishii 1, A Ferrante 1
PMCID: PMC175094  PMID: 9038322

Abstract

The immunoglobulin G (IgG) subclass distribution of antibodies to merozoite surface antigen 2 of Plasmodium falciparum in Solomon Islanders showed marked skewing towards the IgG3 subclass. This was not observed with crude P. falciparum schizont antigen. IgG3 responses may be short-lived and require repeated restimulation for their maintenance. This may be provided by persistent infection (premunition) or new infections.

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Selected References

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