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. 1997 Apr;65(4):1536–1540. doi: 10.1128/iai.65.4.1536-1540.1997

Transcriptional regulation of the Staphylococcus aureus collagen adhesion gene, cna.

A F Gillaspy 1, J M Patti 1, M S Smeltzer 1
PMCID: PMC175166  PMID: 9119500

Abstract

We demonstrate that transcription of the Staphylococcus aureus collagen adhesin gene (cna) is temporally regulated, with expression being highest in exponentially growing cultures and falling to almost undetectable levels as cultures enter the post-exponential-growth phase. The temporal regulation of cna transcription was not affected by mutation of agr. We also demonstrate that the collagen adhesin is expressed by both agr+ and agr-negative S. aureus cells growing in bone.

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Selected References

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