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. 1997 Jan;56(1):17–21. doi: 10.1136/ard.56.1.17

Growth in infancy and bone mass in later life

C Cooper 1, C Fall 1, P Egger 1, R Hobbs 1, R Eastell 1, D Barker 1
PMCID: PMC1752249  PMID: 9059135

Abstract

OBJECTIVE—To examine the association between weight in infancy and bone mass during the seventh decade of life in a population based cohort for which detailed birth and childhood records were preserved.
METHODS—189 women and 224 men who were aged 63-73 years and were born in East Hertfordshire underwent bone densitometry by dual energy x ray absorptiometry. Measurements were also made of serum osteocalcin and urinary excretion of type 1 collagen cross linked N-telopeptide.
RESULTS—There were statistically significant associations between weight at 1 year and bone mineral content (but not bone mineral density) at the spine (P < 0.02) and femoral neck (P < 0.01) among women, and spine (P < 0.03) among men. Although serum osteocalcin was negatively correlated with bone mineral density at both sites among men and women, infant weight was not significantly associated with either biochemical marker of bone turnover.
CONCLUSIONS—These data confirm our previous observations that growth in infancy is associated with skeletal size in adulthood, and suggest that skeletal growth may be programmed during intrauterine or early postnatal life.



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Weight at 1 year and bone mineral content of the lumbar spine (LS-BMC) and femoral neck (FN-BMC) among 224 men and 189 women born in Hertfordshire during 1920-1930. 

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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