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Figure 1 .
(A) Hand radiograph showing pronounced eccentric loss of joint space at the MCP joints, with sclerosis, osteopenia, and radial `hook' osteophytes. (B) Hip radiograph showing attrition of the femoral head with ring cysts. These features are typical of haemochromatosis.
Figure 3 .
Metabolism of PPi and formation of CPPD crystals in haemochromatosis (1) and hypomagnesaemia (2). (1A) Inhibition of alkaline phosphatase by iron, resulting in high values. (1B) The nucleation activity of iron in CPPD crystal formation. (2A) Impaired complexing of PPi with Mg2+ leading to reduced processing to orthophosphate (Pi). (2B) Reduced dissolution of crystals by a Mg2+ dependent pathway.