Abstract
OBJECTIVE—To evaluate serum concentations of cartilage oligomeric matrix protein (COMP) and bone sialoprotein (BSP) as predictors of disease progression in hip osteoarthrtitis (OA). METHODS—Forty eight consecutive patients, referred to hospital for symptomatic hip OA, (ACR criteria) were monitored in a one year prospective trial with radiographs and serum samples. The radiographs were graded for joint space narrowing, osteophytes, and sclerosis and the joint space width was measured by a digitised image analyser. Serum COMP and BSP were quantified by immunoassays. RESULTS—The COMP concentrations at baseline correlated with the joint space width at entry and with its yearly mean narrowing (r = 0.38, p = 0.002) but not with joint space narrowing grade progression. The concentrations were higher in patients with bilateral hip OA (p = 0.03). The serum BSP concentrations at baseline were unrelated to OA progression but correlated inversely to the osteophyte grade (r = −0.36, p = 0.004) and sclerosis grade ( r = −0.42, p = 0.0004). CONCLUSION—Serum COMP seems to be a surrogate marker of OA and may be of interest for the detection of patients at risk of rapidly progressing disease in hip OA. Serum BSP changes seem to reflect alterations in the subchondral bone turnover in hip OA. Measurement of joint space width using a digitised image analyser is a sensitive way of assessing OA progression that facilitates evaluation of tissue markers in relation to anatomical changes in the joint. Keywords: osteoarthritis; hip; cartilage oligomeric matrix protein; bone sialoprotein
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Figure 1 .
Correlation between serum COMP concentration at baseline (µg/ml) and radiographic yearly mean narrowing (YMN mm/year) in 48 patients with with hip OA.
Figure 2 .
Radiographic yearly mean narrowing (YMN mm/year) according to the serum COMP concentration at baseline in 48 patients with in hip OA.
Selected References
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- Altman R. D., Fries J. F., Bloch D. A., Carstens J., Cooke T. D., Genant H., Gofton P., Groth H., McShane D. J., Murphy W. A. Radiographic assessment of progression in osteoarthritis. Arthritis Rheum. 1987 Nov;30(11):1214–1225. doi: 10.1002/art.1780301103. [DOI] [PubMed] [Google Scholar]
- Altman R. D., Hochberg M., Murphy W. A., Jr, Wolfe F., Lequesne M. Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage. 1995 Sep;3 (Suppl A):3–70. [PubMed] [Google Scholar]
- Buckland-Wright J. C. Quantitative radiography of osteoarthritis. Ann Rheum Dis. 1994 Apr;53(4):268–275. doi: 10.1136/ard.53.4.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Conrozier T., Lequesne M. G., Tron A. M., Mathieu P., Berdah L., Vignon E. The effects of position on the radiographic joint space in osteoarthritis of the hip. Osteoarthritis Cartilage. 1997 Jan;5(1):17–22. doi: 10.1016/s1063-4584(97)80028-3. [DOI] [PubMed] [Google Scholar]
- Conrozier T., Tron A. M., Mathieu P., Vignon E. Quantitative assessment of radiographic normal and osteoarthritic hip joint space. Osteoarthritis Cartilage. 1995 Sep;3 (Suppl A):81–87. [PubMed] [Google Scholar]
- Conrozier T., Vignon E. Quantitative radiography in osteoarthritis: computerized measurement of radiographic knee and hip joint space. Baillieres Clin Rheumatol. 1996 Aug;10(3):429–433. doi: 10.1016/s0950-3579(96)80042-2. [DOI] [PubMed] [Google Scholar]
- Dacre J. E., Coppock J. S., Herbert K. E., Perrett D., Huskisson E. C. Development of a new radiographic scoring system using digital image analysis. Ann Rheum Dis. 1989 Mar;48(3):194–200. doi: 10.1136/ard.48.3.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dahlberg L., Roos H., Saxne T., Heinegård D., Lark M. W., Hoerrner L. A., Lohmander L. S. Cartilage metabolism in the injured and uninjured knee of the same patient. Ann Rheum Dis. 1994 Dec;53(12):823–827. doi: 10.1136/ard.53.12.823. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DiCesare P., Hauser N., Lehman D., Pasumarti S., Paulsson M. Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon. FEBS Lett. 1994 Nov 7;354(2):237–240. doi: 10.1016/0014-5793(94)01134-6. [DOI] [PubMed] [Google Scholar]
- Dougados M., Gueguen A., Nguyen M., Berdah L., Lequesne M., Mazieres B., Vignon E. Radiological progression of hip osteoarthritis: definition, risk factors and correlations with clinical status. Ann Rheum Dis. 1996 Jun;55(6):356–362. doi: 10.1136/ard.55.6.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dougados M., Villers C., Amor B. Sensitivity to change of various roentgenological severity scoring systems for osteoarthritis of the hip. Rev Rhum Engl Ed. 1995 Mar;62(3):169–173. [PubMed] [Google Scholar]
- Forslind K., Eberhardt K., Jonsson A., Saxne T. Increased serum concentrations of cartilage oligomeric matrix protein. A prognostic marker in early rheumatoid arthritis. Br J Rheumatol. 1992 Sep;31(9):593–598. doi: 10.1093/rheumatology/31.9.593. [DOI] [PubMed] [Google Scholar]
- Franzén A., Heinegård D. Isolation and characterization of two sialoproteins present only in bone calcified matrix. Biochem J. 1985 Dec 15;232(3):715–724. doi: 10.1042/bj2320715. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hultenby K., Reinholt F. P., Norgård M., Oldberg A., Wendel M., Heinegård D. Distribution and synthesis of bone sialoprotein in metaphyseal bone of young rats show a distinctly different pattern from that of osteopontin. Eur J Cell Biol. 1994 Apr;63(2):230–239. [PubMed] [Google Scholar]
- KELLGREN J. H., LAWRENCE J. S. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957 Dec;16(4):494–502. doi: 10.1136/ard.16.4.494. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kobayashi T., Yoshihara Y., Samura A., Yamada H., Shinmei M., Roos H., Lohmander L. S. Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis. Ann Rheum Dis. 1997 Aug;56(8):500–503. doi: 10.1136/ard.56.8.500. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lane N. E., Nevitt M. C., Genant H. K., Hochberg M. C. Reliability of new indices of radiographic osteoarthritis of the hand and hip and lumbar disc degeneration. J Rheumatol. 1993 Nov;20(11):1911–1918. [PubMed] [Google Scholar]
- Larsson E., Müssener A., Heinegård D., Klareskog L., Saxne T. Increased serum levels of cartilage oligomeric matrix protein and bone sialoprotein in rats with collagen arthritis. Br J Rheumatol. 1997 Dec;36(12):1258–1261. doi: 10.1093/rheumatology/36.12.1258. [DOI] [PubMed] [Google Scholar]
- Ledingham J., Dawson S., Preston B., Milligan G., Doherty M. Radiographic progression of hospital referred osteoarthritis of the hip. Ann Rheum Dis. 1993 Apr;52(4):263–267. doi: 10.1136/ard.52.4.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lequesne M., Brandt K., Bellamy N., Moskowitz R., Menkes C. J., Pelletier J. P., Altman R. Guidelines for testing slow acting drugs in osteoarthritis. J Rheumatol Suppl. 1994 Sep;41:65–73. [PubMed] [Google Scholar]
- Lequesne M. Chondrometry. Quantitative evaluation of joint space width and rate of joint space loss in osteoarthritis of the hip. Rev Rhum Engl Ed. 1995 Mar;62(3):155–158. [PubMed] [Google Scholar]
- Lohmander L. S., Saxne T., Heinegård D. K. Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis. Ann Rheum Dis. 1994 Jan;53(1):8–13. doi: 10.1136/ard.53.1.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lohmander L. S., Saxne T., Heinegård D. Increased concentrations of bone sialoprotein in joint fluid after knee injury. Ann Rheum Dis. 1996 Sep;55(9):622–626. doi: 10.1136/ard.55.9.622. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lynch J. A., Buckland-Wright J. C., Macfarlane D. G. Precision of joint space width measurement in knee osteoarthritis from digital image analysis of high definition macroradiographs. Osteoarthritis Cartilage. 1993 Oct;1(4):209–218. doi: 10.1016/s1063-4584(05)80327-9. [DOI] [PubMed] [Google Scholar]
- Martel W., Adler R. S., Chan K., Niklason L., Helvie M. A., Jonsson K. Overview: new methods in imaging osteoarthritis. J Rheumatol Suppl. 1991 Feb;27:32–37. [PubMed] [Google Scholar]
- Mörgelin M., Heinegård D., Engel J., Paulsson M. Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure. J Biol Chem. 1992 Mar 25;267(9):6137–6141. [PubMed] [Google Scholar]
- Oldberg A., Antonsson P., Lindblom K., Heinegård D. COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins. J Biol Chem. 1992 Nov 5;267(31):22346–22350. [PubMed] [Google Scholar]
- Oldberg A., Jirskog-Hed B., Axelsson S., Heinegård D. Regulation of bone sialoprotein mRNA by steroid hormones. J Cell Biol. 1989 Dec;109(6 Pt 1):3183–3186. doi: 10.1083/jcb.109.6.3183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Petersson I. F., Boegård T., Svensson B., Heinegård D., Saxne T. Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint. Br J Rheumatol. 1998 Jan;37(1):46–50. doi: 10.1093/rheumatology/37.1.46. [DOI] [PubMed] [Google Scholar]
- Saxne T., Heinegård D. Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. Br J Rheumatol. 1992 Sep;31(9):583–591. doi: 10.1093/rheumatology/31.9.583. [DOI] [PubMed] [Google Scholar]
- Saxne T., Zunino L., Heinegård D. Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis. Arthritis Rheum. 1995 Jan;38(1):82–90. doi: 10.1002/art.1780380113. [DOI] [PubMed] [Google Scholar]
- Sharif M., George E., Shepstone L., Knudson W., Thonar E. J., Cushnaghan J., Dieppe P. Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee. Arthritis Rheum. 1995 Jun;38(6):760–767. doi: 10.1002/art.1780380608. [DOI] [PubMed] [Google Scholar]
- Sharif M., Saxne T., Shepstone L., Kirwan J. R., Elson C. J., Heinegård D., Dieppe P. A. Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint. Br J Rheumatol. 1995 Apr;34(4):306–310. doi: 10.1093/rheumatology/34.4.306. [DOI] [PubMed] [Google Scholar]
- Spector T. D., Hart D. J., Nandra D., Doyle D. V., Mackillop N., Gallimore J. R., Pepys M. B. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum. 1997 Apr;40(4):723–727. doi: 10.1002/art.1780400419. [DOI] [PubMed] [Google Scholar]
- Wolfe F. The C-reactive protein but not erythrocyte sedimentation rate is associated with clinical severity in patients with osteoarthritis of the knee or hip. J Rheumatol. 1997 Aug;24(8):1486–1488. [PubMed] [Google Scholar]