Rheumatoid arthritis after human parvovirus B19 infection

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Figure 1  .

Clinical course of patients MI (A) and RM (B). MTX; methotrexate, CRP; C reactive protein, ESR; erythrocyte sedimentation rate, RF; rheumatoid factor.

Figure 2  .

B19 DNA/RNA and VP-1 detected by ISH and immunostaining. Bone marrow cells from patient RM (A) or patient KT with anaemia in control group (B) were hybridised with digoxigenin labelled B19 probe, a 480 base pair fragment between nucleotides 590 and 1090 of B19. B19 DNA/RNA positive signals (brown) are indicated by arrows. B19 DNA/RNA in bone marrow cells from patient MI were hybridised with ³⁶S-dCTP labelled B19 probe, a 480 base pair fragment between nucleotides 590 and 1090 of B19 in 1994 (C) and after immunoglobulin therapy in 1995 (D). Bone marrow cells from patient RM in 1993 (E) and patient YK in control group (F) were stained with monoclonal anti-VP-1, PAR 3,⁸ followed by FITC labelled (Fab)'₂ fragments of antimouse γ.