Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 2000 Nov;59(11):904–909. doi: 10.1136/ard.59.11.904

Lipoproteins and their subfractions in psoriatic arthritis: identification of an atherogenic profile with active joint disease

S Jones 1, C Harris 1, J Lloyd 1, C Stirling 1, J Reckless 1, N McHugh 1
PMCID: PMC1753033  PMID: 11053070

Abstract

OBJECTIVES—(a) To characterise the lipid profile in psoriatic arthritis and investigate whether there are similarities to the dyslipoproteinaemia reported in rheumatoid arthritis and other inflammatory forms of joint disease; (b) to investigate whether there is an atherogenic lipid profile in psoriatic arthritis, which may have a bearing on mortality.
METHODS—Fasting lipids, lipoproteins, and their subfractions were measured in 50 patients with psoriatic arthritis and their age and sex matched controls.
RESULTS—High density lipoprotein cholesterol (HDL cholesterol) and its third subfraction, HDL3 cholesterol, were significantly reduced and the most dense subfraction of low density lipoprotein (LDL), LDL3, was significantly increased in the patients with psoriatic arthritis. Twenty patients with active synovitis had significantly lower total cholesterol, LDL cholesterol, and HDL3 cholesterol than their controls. 25% of the patients with psoriatic arthritis had raised Lp(a) lipoprotein levels (>300 mg/l) compared with 19% of controls, but this was not statistically significant.
CONCLUSION—Raised levels of LDL3 and low levels of HDL cholesterol are associated with coronary artery disease. Such an atherogenic profile in a chronic inflammatory form of arthritis is reported, which may be associated with accelerated mortality.



Full Text

The Full Text of this article is available as a PDF (128.0 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Azzini M., Girelli D., Olivieri O., Guarini P., Stanzial A. M., Frigo A., Milanino R., Bambara L. M., Corrocher R. Fatty acids and antioxidant micronutrients in psoriatic arthritis. J Rheumatol. 1995 Jan;22(1):103–108. [PubMed] [Google Scholar]
  2. Barrett-Connor E., Witztum J. L., Holdbrook M. A community study of high density lipoproteins in adult noninsulin-dependent diabetics. Am J Epidemiol. 1983 Feb;117(2):186–192. doi: 10.1093/oxfordjournals.aje.a113529. [DOI] [PubMed] [Google Scholar]
  3. Beutler B. A., Cerami A. Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells. J Immunol. 1985 Dec;135(6):3969–3971. [PubMed] [Google Scholar]
  4. Brustein D. M., Scher R. K., Auerbach R. Letter: Hyperlipoproteinaemia and psoriasis. Lancet. 1976 Jan 17;1(7951):154–154. doi: 10.1016/s0140-6736(76)93208-6. [DOI] [PubMed] [Google Scholar]
  5. Campos H., Genest J. J., Jr, Blijlevens E., McNamara J. R., Jenner J. L., Ordovas J. M., Wilson P. W., Schaefer E. J. Low density lipoprotein particle size and coronary artery disease. Arterioscler Thromb. 1992 Feb;12(2):187–195. doi: 10.1161/01.atv.12.2.187. [DOI] [PubMed] [Google Scholar]
  6. Castelli W. P., Garrison R. J., Wilson P. W., Abbott R. D., Kalousdian S., Kannel W. B. Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA. 1986 Nov 28;256(20):2835–2838. [PubMed] [Google Scholar]
  7. Fried S. K., Zechner R. Cachectin/tumor necrosis factor decreases human adipose tissue lipoprotein lipase mRNA levels, synthesis, and activity. J Lipid Res. 1989 Dec;30(12):1917–1923. [PubMed] [Google Scholar]
  8. Ilowite N. T., Samuel P., Ginzler E., Jacobson M. S. Dyslipoproteinemia in pediatric systemic lupus erythematosus. Arthritis Rheum. 1988 Jul;31(7):859–863. doi: 10.1002/art.1780310706. [DOI] [PubMed] [Google Scholar]
  9. James R. W., Marini M., Ruiz J., Pometta D. Factors influencing the low density lipoprotein profile in type 2 diabetic patients. Diabet Med. 1995 Jan;12(1):61–65. doi: 10.1111/j.1464-5491.1995.tb02064.x. [DOI] [PubMed] [Google Scholar]
  10. Lazarevic M. B., Vitic J., Mladenovic V., Myones B. L., Skosey J. L., Swedler W. I. Dyslipoproteinemia in the course of active rheumatoid arthritis. Semin Arthritis Rheum. 1992 Dec;22(3):172–178. doi: 10.1016/0049-0172(92)90017-8. [DOI] [PubMed] [Google Scholar]
  11. Lorber M., Aviram M., Linn S., Scharf Y., Brook J. G. Hypocholesterolaemia and abnormal high-density lipoprotein in rheumatoid arthritis. Br J Rheumatol. 1985 Aug;24(3):250–255. doi: 10.1093/rheumatology/24.3.250. [DOI] [PubMed] [Google Scholar]
  12. Maher V. M., Brown B. G. Lipoprotein (a) and coronary heart disease. Curr Opin Lipidol. 1995 Aug;6(4):229–235. doi: 10.1097/00041433-199508000-00007. [DOI] [PubMed] [Google Scholar]
  13. Nigon F., Lesnik P., Rouis M., Chapman M. J. Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor. J Lipid Res. 1991 Nov;32(11):1741–1753. [PubMed] [Google Scholar]
  14. Ogawa H., Nielsen S., Kawakami M. Cachectin/tumor necrosis factor and interleukin-1 show different modes of combined effect on lipoprotein lipase activity and intracellular lipolysis in 3T3-L1 cells. Biochim Biophys Acta. 1989 Jun 8;1003(2):131–135. doi: 10.1016/0005-2760(89)90246-4. [DOI] [PubMed] [Google Scholar]
  16. Pincus T. Long-term outcomes in rheumatoid arthritis. Br J Rheumatol. 1995 Nov;34 (Suppl 2):59–73. [PubMed] [Google Scholar]
  17. Rantapä-Dahlqvist S., Wållberg-Jonsson S., Dahlén G. Lipoprotein (a), lipids, and lipoproteins in patients with rheumatoid arthritis. Ann Rheum Dis. 1991 Jun;50(6):366–368. doi: 10.1136/ard.50.6.366. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rosengren A., Wilhelmsen L., Eriksson E., Risberg B., Wedel H. Lipoprotein (a) and coronary heart disease: a prospective case-control study in a general population sample of middle aged men. BMJ. 1990 Dec 1;301(6763):1248–1251. doi: 10.1136/bmj.301.6763.1248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rosenzweig I. B., Wiebe D. A., Borden E. C., Storer B., Shrago E. S. Plasma lipoprotein changes in humans induced by beta-interferon. Atherosclerosis. 1987 Oct;67(2-3):261–267. doi: 10.1016/0021-9150(87)90287-5. [DOI] [PubMed] [Google Scholar]
  20. Rowe I. F., Soutar A. K., Trayner I. M., Thompson G. R., Pepys M. B. Circulating human C-reactive protein binds very low density lipoproteins. Clin Exp Immunol. 1984 Oct;58(1):237–244. [PMC free article] [PubMed] [Google Scholar]
  21. Rössner S., Löfmark C. Dyslipoproteinaemia in patients with active, chronic polyarthritis. A study on serum lipoproteins and triglyceride clearance (intravenous fat tolerance test). Atherosclerosis. 1977 Sep;28(1):41–52. doi: 10.1016/0021-9150(77)90197-6. [DOI] [PubMed] [Google Scholar]
  22. Salonen J. T., Ylä-Herttuala S., Yamamoto R., Butler S., Korpela H., Salonen R., Nyyssönen K., Palinski W., Witztum J. L. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet. 1992 Apr 11;339(8798):883–887. doi: 10.1016/0140-6736(92)90926-t. [DOI] [PubMed] [Google Scholar]
  23. Samsioe G. Cardioprotection by estrogens: mechanisms of action--the lipids. Int J Fertil Menopausal Stud. 1994;39 (Suppl 1):43–49. [PubMed] [Google Scholar]
  24. Spriggs D. R., Sherman M. L., Michie H., Arthur K. A., Imamura K., Wilmore D., Frei E., 3rd, Kufe D. W. Recombinant human tumor necrosis factor administered as a 24-hour intravenous infusion. A phase I and pharmacologic study. J Natl Cancer Inst. 1988 Sep 7;80(13):1039–1044. doi: 10.1093/jnci/80.13.1039. [DOI] [PubMed] [Google Scholar]
  25. Svenson K. L., Lithell H., Hällgren R., Selinus I., Vessby B. Serum lipoprotein in active rheumatoid arthritis and other chronic inflammatory arthritides. I. Relativity to inflammatory activity. Arch Intern Med. 1987 Nov;147(11):1912–1916. [PubMed] [Google Scholar]
  26. Terres W., Tatsis E., Pfalzer B., Beil F. U., Beisiegel U., Hamm C. W. Rapid angiographic progression of coronary artery disease in patients with elevated lipoprotein(a) Circulation. 1995 Feb 15;91(4):948–950. doi: 10.1161/01.cir.91.4.948. [DOI] [PubMed] [Google Scholar]
  27. Winyard P. G., Tatzber F., Esterbauer H., Kus M. L., Blake D. R., Morris C. J. Presence of foam cells containing oxidised low density lipoprotein in the synovial membrane from patients with rheumatoid arthritis. Ann Rheum Dis. 1993 Sep;52(9):677–680. doi: 10.1136/ard.52.9.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Zambon A., Austin M. A., Brown B. G., Hokanson J. E., Brunzell J. D. Effect of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb. 1993 Feb;13(2):147–153. doi: 10.1161/01.atv.13.2.147. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES