Abstract
OBJECTIVE—To ascertain by cross sectional examination whether the concentration of procollagen IIC-peptide in joint fluid significantly correlates with mechanical risk factors of knee osteoarthritis (OA), such as obesity (body mass index) and varus alignment (lateral femorotibial angle). METHODS—The concentrations of procollagen IIC-propeptide in synovial fluid were measured by a sandwich enzyme immunoassay of 65 patients with the same radiological stage of primary knee OA—that is, Ahlbäk stage I. The relations between procollagen IIC-peptide and body mass index and lateral femorotibial angle were examined using simple regression analysis and multiple regression analysis. RESULTS—Significant positive correlations were found between procollagen IIC-propeptide concentrations and body mass index (r=0.479, p<0.0001), and between procollagen IIC-propeptide concentrations and lateral femorotibial angle (r=0.375, p=0.0021). Significant correlations were also found by multiple regression analysis. The multiple correlation coefficient of body mass index and femorotibial lateral angle to the procollagen IIC-propeptide concentrations was 0.547 (p<0.0001). CONCLUSIONS—The findings suggest that synthesis of type II collagen by chondrocytes is enhanced by abnormal mechanical stress, in this case obesity and varus alignment. It is concluded that procollagen IIC-propeptide concentrations in joint fluid are a useful marker of early OA.
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Figure 1 .
Correlation between procollagen IIC-peptide concentrations and body mass index (BMI). Procollagen IIC-propeptide concentrations in joint fluid were measured by enzyme immunoassay. Significant correlations were found between procollagen IIC-propeptide concentrations in joint fluid and BMI in 65 patients with primary knee osteoarthritis, Ahlbäk stage I (r=0.479, p<0.0001).
Figure 2 .
Correlation between procollagen IIC-peptide concentrations and lateral femorotibial angle (FTA). Significant correlations were also found between procollagen IIC-propeptide concentrations in joint fluid and the FTA in 65 patients with primary knee osteoarthritis, Ahlbäk stage I (r=0.375, p=0.0021).